5-Amino-2-fluoropyridine Chemical Properties

Melting point:

86-87°C

Boiling point:

264.0±20.0 °C(Predicted)

Density 

1.257±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

2?+-.0.10(Predicted)

form 

powder to crystal

color 

Purple to Dark purple to Dark red

CAS DataBase Reference

1827-27-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-41-37/38

Safety Statements 

26-36/37/39

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

6.1

HS Code 

29333990

5-Amino-2-fluoropyridine Usage And Synthesis

Chemical Properties

Light yellow Cryst

Uses

5-Amino-2-fluoropyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Synthesis

General procedure for the synthesis of 2-fluoro-5-aminopyridine from 2-fluoro-5-nitropyridine: 50 mL of toluene and 50 mmol of 2-fluoro-5-nitropyridine were added to a 100 mL round-bottomed flask, followed by 0.282 g of 5% Pd/C catalyst and 10 mmol of anhydrous sodium sulfate. The reaction system was placed under hydrogen atmosphere, heated and stirred for 15 hours. Upon completion of the reaction, the mixture was cooled to room temperature, the catalyst was removed by filtration and the filtrate was concentrated by rotary evaporation. The resulting crude product was purified by recrystallization and finally dried under vacuum to give 1.6806 g of 2-fluoro-5-aminopyridine solid in 75% yield.

References

[1] Journal of the Chemical Society - Perkin Transactions 1, 1996, # 18, p. 2221 - 2226
[2] Patent: CN103755744, 2016, B. Location in patent: Paragraph 0065; 0066
[3] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 6, p. 1411 - 1416
[4] Patent: US6355636, 2002, B1. Location in patent: Page column 64
[5] Patent: EP1171440, 2004, B1. Location in patent: Page 53

5-Amino-2-fluoropyridine(1827-27-6)Related Product Information

• 3-Aminobenzotrifluoride
• 4-Aminopyridine
• 3-Aminophenol
• 3-Aminopyridine
• 5-Amino-2-methylpyridine
• ALTRENOGEST
• 2-Fluoropyridine
• 4-Dimethylaminopyridine
• Glycine
• 6-Aminocaproic acid
• 2-Fluoro-5-nitropyridine
• 3-AMINO-2-FLUOROPYRIDINE,3-AMINO-2-FLUOROPYRIDINE
• Tris(hydroxymethyl)aminomethane
• 2-Fluoro-6-methylpyridine
• 5-Bromo-2-fluoropyridine
• 5-Chloro-2-fluoropyridine
• 2-Fluoropyridine-6-carboxylic acid
• 2-Fluoro-3-nitropyridine