6-Nitroindazole
6-Nitroindazole Basic information
- Product Name:
- 6-Nitroindazole
- Synonyms:
-
- 1H-Indazole, 6-nitro-
- 6-nitro-1h-indazol
- 6-Nitroisoindazole
- 6-NITRO-1H-INDAZOLE
- 6-NITROINDAZOLE
- 6-Nitro-1(2)H-indazole
- 6-Nitroindazole ,97%
- 6-Nitroindazole,98%
- CAS:
- 7597-18-4
- MF:
- C7H5N3O2
- MW:
- 163.13
- EINECS:
- 231-500-9
- Product Categories:
-
- Inhibitors
- Nitric Oxide Reagents
- Heterocyclic Compounds
- All Inhibitors
- Building Blocks
- Heterocyclic Building Blocks
- Indazoles
- Intermediate
- Mol File:
- 7597-18-4.mol
6-Nitroindazole Chemical Properties
- Melting point:
- 180-182 °C (lit.)
- Boiling point:
- 290.19°C (rough estimate)
- Density
- 1.4141 (rough estimate)
- refractive index
- 1.5500 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- very faint turbidity in hot Methanol
- pka
- 11.08±0.40(Predicted)
- form
- Powder
- color
- Light Yellow
- BRN
- 7812
- CAS DataBase Reference
- 7597-18-4(CAS DataBase Reference)
- NIST Chemistry Reference
- 6-Nitroindazole(7597-18-4)
- EPA Substance Registry System
- 1H-Indazole, 6-nitro- (7597-18-4)
Safety Information
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-36/37/38-40-68-36
- Safety Statements
- 26-27-36/37/39
- WGK Germany
- 3
- RTECS
- NK7962100
- TSCA
- Yes
- HS Code
- 29339900
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
6-Nitroindazole Usage And Synthesis
Description
6-Nitroindazole is a competitive and reversible Monoamine oxidase(MAO)inhibitor. It can inhibit MAO-A and MAO-B (IC50= 2.5 μM). Monoamine oxidase (MAO) B is a mitochondrial enzyme selectively involved in the oxidative activation of 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to toxic pyridinium cations producing Parkinsonism in animal models. In addition, it is an nNOS inhibitor, which has neuroprotective effects[1].
Chemical Properties
yellow powder
Uses
Anticonvulsant.
Synthesis
6-Nitroindazole is prepared by (2-methyl-5-nitrophenyl)azo phenyl sulfide and 1,8-diazabicyclo[5.4.0]undec-7-ene in the presence of concentrated acetonitrile.
References
[1] HERRAIZTOMAS GuillénHugo AránVicente J. Nitroindazole compounds inhibit the oxidative activation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to neurotoxic pyridinium cations by human monoamine oxidase (MAO).[J]. Free Radical Research, 2009: 975-984. DOI:10.1080/10715760903159170.
6-Nitroindazole Preparation Products And Raw materials
Raw materials
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6-Nitroindazole(7597-18-4)Related Product Information
- 3-Methyl-6-nitroindazole
- 3-Nitroacetophenone
- Sodium 3-nitrobenzenesulphonate
- 2-Ethyl-5-nitrobenzenamine ,98%
- 5-Amino-2-methylbenzenesulfonamide
- N4-(2,3-Dimethyl-2H-indazol-6-yl)-N4-methyl-2,4-pyrimidinediamine
- Pazopanib Impurity 48
- 3-methyl-1H-indazol-6-amine
- 5-Amino-2,3-dimethyl-2H-indazole
- Pazopanib Impurity 32
- 2,4-Dichloropyrimidine
- Benzenamine, 2-ethyl-4-nitro-
- 3-AMINO-4-METHYLBENZENESULFONAMIDE
- 2-amino-5-methylbenzenesulfonamide
- Pazopanib-d6
- 2H-Indazol-4-amine, 2,3-dimethyl-
- 1H-Indazol-6-amine, N-(2-chloro-4-pyrimidinyl)-3-methyl-
- Pazopanib Impurity 47