2,4-Difluorobenzyl alcohol Chemical Properties

Boiling point:

52 °C

Density 

1.29 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.487(lit.)

Flash point:

194 °F

storage temp. 

Sealed in dry,Room Temperature

form 

clear liquid

pka

13.82±0.10(Predicted)

color 

Colorless to Light orange to Yellow

Specific Gravity

1.290

BRN 

2501944

CAS DataBase Reference

56456-47-4(CAS DataBase Reference)

NIST Chemistry Reference

2,4-Difluorobenzyl alcohol(56456-47-4)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HazardClass 

IRRITANT

PackingGroup 

III

HS Code 

29062990

MSDS

• Language:English Provider:2,4-Difluorobenzyl alcohol
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2,4-Difluorobenzyl alcohol Usage And Synthesis

Chemical Properties

CLEAR COLORLESS LIQUID

Synthesis

To a stirred solution of 2,4-difluorobenzaldehyde (500 mg, 3.52 mmol) in CH3OH (8 mL) was added NaBH4(266 mg, 7.04 mmol) portion wise at 0° C., and the reaction mixture was stirred at 0° C. for 1 h. After completion of the reaction (by TLC), CH3OH was removed under reduced pressure, diluted with ice-cold H2O (40 mL) and extracted with EtOAc (2.x.20 mL). The combined organic layers were washed with H2O (40 mL) and brine (40 mL), dried over anhydrous Na2SO4and concentrated under reduced pressure to obtain the crude material. Purification by silica gel column chromatography eluting with 10percent EtOAc/hexanes afforded 2,4-Difluorobenzyl alcohol (450 mg, 3.12 mmol, 88percent) as colorless liquid. 1H NMR (200 MHz, CDCl3): δ 7.45-7.33 (m, 1H), 6.83-6.75 (m, 2H), 4.72 (s, 2H), 1.79 (br s, OH).

2,4-Difluorobenzyl alcohol(56456-47-4)Related Product Information

• Phenethyl alcohol
• 4-Nitrobenzyl alcohol
• 3-Fluorobenzyl alcohol
• Benzyl alcohol
• 1,2-Difluorobenzene
• Ethyl acetate
• alpha-Chloro-o-fluorotoluene
• Haloperidol
• Florfenicol
• Transfluthrin
• 4-Fluorobenzyl chloride
• 1,3-Difluorobenzene
• [2,3,5,6-tetrafluoro-4-(methoxymethyl)phenyl]methyl 2,2-dimethyl-3-pro p-1-enyl-cyclopropane-1-carboxylate
• Pentafluorobenzoic acid
• O-(2,3,4,5,6-PENTAFLUOROBENZYL)HYDROXYLAMINE HYDROCHLORIDE
• 2,3,4,5-Tetrafluorobenzoic acid
• ETHYL PENTAFLUOROBENZOATE
• Tetrafluorophthalic acid