2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE Chemical Properties

Melting point:

78-83 °C

Boiling point:

114°C/10mmHg(lit.)

Density 

1.23

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

soluble in Methanol

pka

10.75±0.20(Predicted)

form 

Powder

color 

White

Water Solubility 

Slightly soluble in water.

λmax

306nm(Cyclohexane)(lit.)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36

Safety Statements 

36

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29339900

2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE Usage And Synthesis

Chemical Properties

Beige powder

Uses

It can be used as pharmaceutical raw material and intermediate.

Synthesis

a) 7-azaindole (100 g, 0.846 mol), Ni/Al?O? catalyst (12 g, 10 wt%), and toluene (200 g) were added to the autoclave and stirred and mixed homogeneously to obtain the reaction solution A; b) the autoclave was replaced with nitrogen for 8 times, followed by hydrogen for 4 times to ensure that the reaction system was oxygen-free; c) the reaction solution A was subjected to hydrogenation reaction at a pressure of 2 MPa hydrogen and 130 °C; d) after the completion of the reaction, the hydrogenation mixture was filtered to remove the catalyst to obtain the filtrate B; e) after distillation and recovery of the organic solvent from the filtrate B, 2,3-dihydro-1H-pyrrolo[2,3-b]pyridine (94.59 g, 93.4% yield) was obtained, and the purity of the product was analyzed by gas chromatography, which was ≥98%.

References

[1] Patent: CN107987076, 2018, A. Location in patent: Paragraph 0043-0047; 0058-0063; 0075-0079
[2] Patent: CN106188050, 2016, A. Location in patent: Paragraph 0016
[3] Patent: US2011/144105, 2011, A1. Location in patent: Page/Page column 16
[4] Synthesis, 2005, # 15, p. 2503 - 2506
[5] Patent: WO2004/78757, 2004, A2. Location in patent: Page 32; 48-49

2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE(10592-27-5)Related Product Information

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• 2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBOXYLIC ACID
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• PGP-4008