4-Methoxypyridine Chemical Properties

Melting point:

4 °C

Boiling point:

108-111 °C/65 mmHg (lit.)

Density 

1.075 g/mL at 25 °C (lit.)

refractive index 

1.518-1.522

Flash point:

74 °C

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Liquid

pka

6.58(at 25℃)

Specific Gravity

1.075

color 

Clear colorless to slightly yellow

BRN 

108211

InChI

InChI=1S/C6H7NO/c1-8-6-2-4-7-5-3-6/h2-5H,1H3

InChIKey

XQABVLBGNWBWIV-UHFFFAOYSA-N

SMILES

C1=NC=CC(OC)=C1

CAS DataBase Reference

620-08-6(CAS DataBase Reference)

NIST Chemistry Reference

Pyridine, 4-methoxy-(620-08-6)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

36/37/38-20/21/22

Safety Statements 

37/39-26-36-36/37/39

WGK Germany 

3

HS Code 

29339900

Storage Class

10 - Combustible liquids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

MSDS

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• Language:English Provider:ALFA

4-Methoxypyridine Usage And Synthesis

Chemical Properties

clear colorless to slightly yellow liquid

Uses

4-Methoxypyridine, is used as a building block for the synthesis of some biologically active compounds. It is used for the preparation of a new series of benzoylated N-ylides as protein farnesyltransferase inhibitors.

Uses

4-Methoxypyridine was used as a starting reagent for the stereocontrolled synthesis of (±)-pumiliotoxin C and (±)-lasubine II. It was also used in an efficient construction of dihyropyridin-4-ones, which serves as potential ligands for neuronal nicotinic acetycholine receptors.

General Description

4-Methoxypyridine has been prepared from 4-methoxypyridine-N-oxide, via catalytic hydrogenation. Ortho lithiation of 4-methoxypyridine using mesityllithium as the metalating base has been studied.

Synthesis

At room temperature, (50mmo1) 4-methoxypyridine-N-oxide was dissolved in 50mL acetonitrile solution, then 1.01g (55mmo1) tritiated cyanogen chloride (TCT) was added to the reaction solution in batches, and the reaction was tracked by TCL, and at the end of the reaction, 20mL of saturated sodium carbonate solution was added dropwise to the reaction solution, and the reaction was stirred for 30min. dichloromethane was added to extract, and the organic phase was respectively The organic phase was washed with water and saturated saline, and the crude product was obtained by spinning off the solvent under reduced pressure. The crude product was purified by column to get the target product. Light yellow oily liquid.

4-Methoxypyridine(620-08-6)Related Product Information

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• 4-METHOXY-2-QUINOLINECARBOXYLIC ACID
• 4-METHOXYPYRIDINE-N-OXIDE HYDRATE, 99
• 4-Methoxy-3-nitropyridine
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• 4-METHOXY-3-NITROPYRIDINE HYDROCHLORIDE
• p-methoxypyridine n-oxide
• 5-FLUORO-4-IODO-2-METHOXYPYRIDINE
• 2-Methoxypyridine