5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole Chemical Properties

Melting point:

152-155°C

Boiling point:

61°C/12mmHg(lit.)

Density 

1.28±0.1 g/cm3(Predicted)

storage temp. 

Inert atmosphere,2-8°C

solubility 

Soluble in Chloroform and Methanol (Sparingly)

form 

Solid

pka

0.29±0.10(Predicted)

color 

White

Stability:

Moisture Sensitive

InChI

InChI=1S/C33H25BrN4/c34-24-25-20-22-26(23-21-25)30-18-10-11-19-31(30)32-35-36-37-38(32)33(27-12-4-1-5-13-27,28-14-6-2-7-15-28)29-16-8-3-9-17-29/h1-23H,24H2

InChIKey

ZTFVTXDWDFIQEU-UHFFFAOYSA-N

SMILES

N1(C(C2=CC=CC=C2)(C2=CC=CC=C2)C2=CC=CC=C2)C(C2=CC=CC=C2C2=CC=C(CBr)C=C2)=NN=N1

CAS DataBase Reference

124750-51-2(CAS DataBase Reference)

Safety Information

RIDADR 

UN 2811 6.1/PG III

HazardClass 

6.1

PackingGroup 

III

5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole Usage And Synthesis

Description

5-[4′-Bromomethyl-(1,1′-biphenyl)-2-yl]-1-triphenylmethyltetrazole is an intermediate in the synthesis of Losartan and Valsartan. Utilized for various purposes, 5-[4′-Bromomethyl-(1,1′-biphenyl)-2-yl]-1-triphenylmethyltetrazole has found application as a fluorescent probe to identify DNA damage. It serves as a photosensitizer in photodynamic therapy and acts as a catalyst in polymer synthesis. Furthermore, this compound functions as a fluorescent label to detect proteins and as a fluorescent indicator to detect metal ions.

Chemical Properties

Off-White Solid

Uses

Used as Olmesartan medoxomil related intermediate, Olmesartan medoxomil is an angiotensin II receptor antagonist^[1]. 

Application

5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole is an important pharmaceutical intermediate. It can be used in the preparation of olmesartan medoxomil key intermediates, Losartan potassium, Valsartan, Candesartan and molecular sieve catalysts.

Hazard

5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole has an acute toxin and is irritating to skin and eyes.

References

[1] HAI Z. Determination of the related substances in N-triphenylmethyl-5-(4’-bromomethylbiphenyl-2-yl-) terazole by HPLC[J]. West China Journal of Pharmaceutical Sciences, 2015.

5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole(124750-51-2)Related Product Information

• 4,4'-Dimethylbiphenyl
• Decabromodiphenyl oxide
• FIREMASTER BP-6
• Biphenyl
• 2-Bromobiphenyl
• 2,3,5-Triphenyltetrazolium chloride
• 2-(1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-2-butyl-4-Methyl-6-oxo-1,6-dihydropyriMidin-5-yl) -N,N-diMethylacetaMide
• Fimasartan
• 2-Butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-5-pyrimidineacetamide
• 2-(2-butyl-4-hydroxy-6-MethylpyriMidin-5-yl)-N,N-diMethylacetaMide
• OlMesartan MedoxoMil iMpurity V
• N-Trityl Olmesartan Ethyl Ester
• METHYL TRIPHENYLMETHYL ETHER
• 2-(2-butyl-4-Methyl-6-oxo-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-1,6-dihydropyriMidin-5-yl)-N,N-diMethylethanethioaMide
• 4-(1-Methoxy-1-methylethyl)-2-propyl-1H-Imidazole-5-carboxylic acid ethyl ester
• Diethyl 2-propylImidazoledicarbonate
• OlMesartan MedoxoMil Butyl IMpurity
• 4,5-Dimethyl-1,3-dioxol-2-one