PAF (C18) Chemical Properties

storage temp. 

-20°C

solubility 

chloroform: 10 mg/mL

Safety Information

Safety Statements 

24/25

WGK Germany 

3

HS Code 

29310099

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

PAF (C18) Usage And Synthesis

Chemical Properties

white solid

Uses

C18-02:0 PC or 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine is suitable as a substrate for enzymatic lipoprotein-associated phospholipase A2 (Lp-PLA2) activity assay.

Uses

C18-02:0 PC or 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine may be used as a substrate in enzymatic lipoprotein-associated phospholipase A2 (Lp-PLA2) activity assay.

Definition

ChEBI: 2-acyl-1-alkyl-sn-glycero-3-phosphocholine betaine in which the 1-alkyl and 2-acyl groups are specified as octacdecyl and acetyl respectively

General Description

C18-02:0 PC, also known as 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine (C18∶0-PAF), is a platelet-activating factor lipid. It belongs to a class of natural PAFs and is produced in basophil leucocytes, macrophages, polymorphonuclear neutrophils and monocytes and platelets.

Biochem/physiol Actions

C18-02:0 PC or 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine (C18-PAF), a platelet-activating factor (PAF) facilitates platelet aggregation and secretion. It also plays a key role in inflammation and anaphylaxis. C18-PAF exhibits neurotoxic effects by initiating caspase-independent death in PAF receptor-deficient neurons.

PAF (C18)(74389-69-8)Related Product Information

• 2-O-METHYL PAF C-18
• 1,2-Distearoyl-sn-glycero-3-phosphocholine
• 1,2-DINONADECANOYL-SN-GLYCERO-3-PHOSPHATIDYLCHOLINE
• 1,2-DISTEAROYL-D70-3-SN-GLYCEROPHOSPHATIDYLCHOLINE
• 1-STEAROYL-2-PALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
• 1,2-DIEICOSANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
• 1-OCTADECANOYL-2-[(CIS,CIS,CIS,CIS)-5,8,11,14-EICOSATETRAENOYL]-SN-GLYCERO-3-PHOSPHOCHOLINE
• LYSO-PAF (C18)
• 2-O-METHYL PAF C-18
• 1-OCTADECANOYL-2-[CIS-9-OCTADECENOYL]-SN-GLYCERO-3-PHOSPHOCHOLINE
• PAF (C18)
• 1-stearoyl-2-linoleoylphosphatidylcholine
• 1,2-DIDOCOSANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
• ENANTIO-PAF (C18)
• DEHYDRO-LYSO-PAF (C18)
• 1-O-Octadecyl-2-acetyl-sn-glycero-3-phosphocholine, PAF(C18)
• PAF C-18:1,Dehydro-PAF(C18), L-α-Phosphatidylcholine, β-acetyl-γ-O-(octadec-9-cis-enyl),DEHYDRO-PAF (C18)
• LYSOLECITHIN PAF(C18)