(PHE1,SER2,TYR6)-PAR-1 (1-6) AMIDE (HUMAN) Chemical Properties

storage temp. 

-20°C

solubility 

Acetonitrile: 0.5 mg/ml; DMSO: 20 mg/ml

form 

powder

color 

white to off-white

Water Solubility 

Soluble to 1 mg/ml in water

Safety Information

WGK Germany 

3

(PHE1,SER2,TYR6)-PAR-1 (1-6) AMIDE (HUMAN) Usage And Synthesis

Uses

L-Phenylalanyl-L-seryl-L-leucyl-L-leucyl-L-arginyl-L-tyrosinamide, is a peptide agonist of proteinase-activated receptor1,and 2 (PAR-1 and -2), and thus can be used to study PAR1,2 action in cells and in animals.

Biological Activity

FSLLRY-NH2 is a peptide antagonist of the protease activated receptor 2 (PAR2). The peptide blocks agonist induced itching in rodent models. In cell based assays, the peptide inhibits agonist-induced cardiocyte remodeling, and production of cytokines by endothelial cells.', 'The ability of FSLLRY-NH2 to decrease visceral hypersensitivity (VH) suggests th at PAR2 is involved in the maintenance of VH.

storage

-20°C

(PHE1,SER2,TYR6)-PAR-1 (1-6) AMIDE (HUMAN)(245329-02-6)Related Product Information

• H-SER-LEU-ILE-GLY-ARG-LEU-OH
• H-GLY-TYR-PRO-GLY-LYS-PHE-NH2
• H-GLY-TYR-PRO-GLY-GLN-VAL-OH
• VKGILS-NH2