DFMO Chemical Properties

Melting point:

138 °C

Boiling point:

347.0±42.0 °C(Predicted)

Density 

1.1800 (estimate)

storage temp. 

Store at 0°C

solubility 

H₂O: >10 mg/mL, soluble

form 

solid

pka

1.22±0.44(Predicted)

color 

white

Safety Information

WGK Germany 

3

Hazardous Substances Data

70052-12-9(Hazardous Substances Data)

DFMO Usage And Synthesis

Chemical Properties

Off-white powder

Uses

DL-α-Difluoromethylornithine hydrochloride hydrate has been used to reduce the effects of arginine on cell proliferation. It has also been used to investigate the effect of bisphenol A (BPA) on the migration of an established ovine trophectoderm (oTr1) cell line.

Definition

ChEBI: Eflornithine is a fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2. It has a role as a trypanocidal drug. It is a fluoroamino acid and an alpha-amino acid. It is functionally related to an ornithine.

General Description

Difluoromethylornithine is a?fluorinated ornithine analog, which acts as a rate-limiting enzyme of polyamine biosynthesis. It is used to treat female facial hirsutism and human African trypanosomiasis. Difluoromethylornithine functions as a chemopreventive and chemotherapeutic agent against neuroblastoma and colorectal cancer. It exhibits cytostatic?effects on mammalian cells and tissues.

Biological Activity

Inhibitor of ornithine decarboxylase that inhibits polyamine biosynthesis. Displays antiapoptotic, antiangiogenic and antiparasitic activity.

Biochem/physiol Actions

Difluoromethylornithine (Eflornithine) inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis.

DFMO(70052-12-9)Related Product Information

• 3-Hydroxyphenyl acetate
• racephedrine
• Acetonitrile
• DFMO
• DFMO-PCV protocol
• DFMO EFLORNITHINE
• (S)-2-AMINO-2-METHYLBUTYRIC ACID
• BETA-FLUORO-DL-ALANINE
• 2,5-DIAMINO-2-METHYL-PENTANOIC ACID HCL
• DFMO
• DFMO,DFMO HCL,DFMO HYDROCHLORIDE
• DFMO
• 2-FLUORO-1,1-DIMETHYL-ETHYLAMINE HCL-SALT