Gomisin A
Gomisin A Basic information
- Product Name:
- Gomisin A
- Synonyms:
-
- 2,3,13-tetramethoxy-l-stereoisomer
- benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxol-6-ol,5,6,7,8-tetrahydro-6,7-dimethy
- wuweizialcoholb
- wuweizichunb
- BESIGOMISIN
- GOMISIN A
- SCHISANDROL B
- SCHIZANDROL B
- CAS:
- 58546-54-6
- MF:
- C23H28O7
- MW:
- 416.47
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- Miscellaneous Natural Products
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Mol File:
- 58546-54-6.mol
Gomisin A Chemical Properties
- Melting point:
- 88.5°C
- Boiling point:
- 454.79°C (rough estimate)
- Density
- 1.1772 (rough estimate)
- refractive index
- 1.5300 (estimate)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO : 50 mg/mL (120.06 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
- form
- powder to crystal
- pka
- 14.58±0.40(Predicted)
- color
- White to Light yellow
- LogP
- 4.770 (est)
Safety Information
- Safety Statements
- 24/25
- HS Code
- 29329990
Gomisin A Usage And Synthesis
Description
Schisandrol B is a lignan originally isolated from S. chinensis that has hepatoprotective activity. It increases the expression of pregnane X receptor (PXR) target genes involved in bile acid metabolism, including Cyp3a11, Ugt1a1, Oatp2, and Mrp3 in mouse liver and CYP3A4, UGT1A1, and OATP2 in HEK293T cells. It also protects against lithocholic acid-induced hepatic necrosis and intrahepatic cholestasis in wild-type, but not Pxr-null, mice and decreases mortality in a mouse model of cholestasis when administered at a dose of 100 mg/kg twice per day. It also promotes liver regeneration following partial hepatectomy and protects against hepatotoxicity induced by acetaminophen .
Chemical Properties
White powder
Uses
Schizandrol B exhibits potent protective effects of on ET-1-induced dysfunctional human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs). Anti-cholestasis effect.
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Gomisin A(58546-54-6)Related Product Information
- Gomisin C(Schisantherin A)
- Schisandrin A
- Nortropine
- GOMISIN N
- Schisandrin
- Silibinin
- Ginkgo biloba extract
- WUWEIZISU C
- (5S)-6α,7β-Dimethyl-1,2,3,11,12-pentamethoxy(5,6,7,8-tetrahydrodibenzo[a,c]cyclooctene)-5α,6β,10-triol 5-benzoate
- 2-BUTENOIC ACID, 2-METHYL-, (5S,6S,7S,13AS)-5,6,7,13A-TETRAHYDRO-6-HYDROXY-1,2,3,13-TETRAMETHOXY-6,7-DIMETHYLBENZO[3,4]CYCLOOCTA[1,2-F][1,3]BENZODIOXOL-5-YL ESTER, (2Z)-
- Benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxol-1-ol, 5,6,7,8-tetrahydro-2, 3,13-trimethoxy-6,7-dimethyl-, stereoisomer
- SCHISANTHERIN C 98+% HPLC
- Gomisin K3
- GOMISIN,GOMISIN C
- SCHISANDROL B (GOMISIN A)(P),SCHISANDROL B(GOMISIN A) SNAP-N-SHOOT 0.1mg/mL(P),Gomisin A(Schisandrol B)
- Masoprocol
- Gomisin B(Schisantherin B)
- Dihydromyristicin