CATECHOL O-METHYLTRANSFERASE Chemical Properties

storage temp. 

−20°C

form 

lyophilized powder

color 

White to off-white

EPA Substance Registry System

Methyltransferase, catechol (9012-25-3)

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

CATECHOL O-METHYLTRANSFERASE Usage And Synthesis

Uses

Catechol O-methyltransferase, porcine liver (COMT), the magnesium-dependent transfer of methyl groups from S-adenosyl methionine to a hydroxyl group on dopamine, converting it to 3-methoxytyramine. Catechol O-methyltransferase has two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). Catechol O-methyltransferase is to regulate epinephrine, norepinephrine, and dopamine levels in the brain[1].

Definition

Any of a class of enzymesthat catalyze the transfer of a methyl group toan organic molecule. The methyl donor is s-adenosylmethionine, formed from methionine andATP.

References

[1] Du X, et, al. A catechol-O-methyltransferase that is essential for auditory function in mice and humans. Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14609-14. DOI:10.1073/pnas.0807219105

CATECHOL O-METHYLTRANSFERASE(9012-25-3)Related Product Information

• METHYL ISOCYANOACETATE
• TERT-BUTYL ISOCYANIDE
• SALCOMINE
• Aluminum acetylacetonate
• TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III)
• Ethyl isocyanoacetate
• TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)
• Benzyl isocyanide
• 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE
• N-BUTYLISOCYANIDE
• Tris(2,4-pentanedionato)chroMiuM(III)
• PHENYLSELENOL
• 2,4-PENTANEDIONE, SILVER DERIVATIVE
• Tosylmethyl isocyanide
• COBALT(II) ACETYLACETONATE
• DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
• Cupric acetylacetonate
• S-Adenosyl-L-methionine