2,3,6-TRICHLOROPYRIDINE Chemical Properties

Melting point:

66-67 °C

Boiling point:

300.44°C (rough estimate)

Density 

1.8041 (rough estimate)

refractive index 

1.6300 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

soluble in Methanol

form 

powder to crystal

pka

-3.79±0.10(Predicted)

color 

Light yellow to Brown

InChI

InChI=1S/C5H2Cl3N/c6-3-1-2-4(7)9-5(3)8/h1-2H

InChIKey

GPAKJVMKNDXBHH-UHFFFAOYSA-N

SMILES

C1(Cl)=NC(Cl)=CC=C1Cl

EPA Substance Registry System

2,3,6-Trichloropyridine (6515-09-9)

Safety Information

HS Code 

2933399990

Toxicity

LD50 ipr-mus: 150 mg/kg TXAPA9 11,361,67

2,3,6-TRICHLOROPYRIDINE Usage And Synthesis

Uses

2,3,6-Trichloropyridine can be used as a catalyst for various compounds, such as, 2,3-dichloropyridine. This compound can also be used as an intermediate in chemosynthesis.

Safety Profile

A poison by intraperitoneal route.When heated to decomposition it emits toxic vapors ofNOx and Clí.

Synthesis

The general procedure for the synthesis of 2,3,6-trichloropyridine from 2,6-dichloropyridine was as follows: 2,6-dichloropyridine 1480.0 g and anhydrous FeCl3 89.2 g were accurately weighed, mixed thoroughly and transferred to a 2000 mL four-neck flask. The reaction mixture was heated to 100-120 °C and then chlorine gas was slowly introduced until the reaction was complete. Upon completion of the reaction, the system was cooled to 100 °C and subsequently subjected to decompression distillation. Fractions with boiling points of 118-124°C were collected as products at a pressure of -12.8 MPa. The low concentration of distillate produced during the distillation process can be recycled for the next batch of reaction. Eventually, 1715.0 g of 2,3,6-trichloropyridine was obtained by recycling the distillate in 94.0% yield, and the purity of the product was in accordance with the requirements.

References

[1] Patent: EP2687510, 2014, A1. Location in patent: Paragraph 0011
[2] Patent: CN107759512, 2018, A. Location in patent: Paragraph 0021-0022

2,3,6-TRICHLOROPYRIDINE(6515-09-9)Related Product Information

• 3-Cyanopyridine
• 2-Cyanopyridine
• 3-Picoline
• Pentachloropyridine
• 3-Aminopyridine
• 2,3,5,6-Tetrachloropyridine
• 2,3-Dichloropyridine
• 2,6-Dichloropyridine
• 2,3,6-Trichloropyridine