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4-(Chloromethyl)pyridine hydrochloride

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4-(Chloromethyl)pyridine hydrochloride Basic information

Product Name:
4-(Chloromethyl)pyridine hydrochloride
Synonyms:
  • 4-(chloromethyl)pyridin-1-ium chloride
  • 4-(Chloromethyl) Pyridine HCL 99%
  • 4-(Chloromethyl)pyridine hydrochloride ,98%
  • 4-Chloromethylpyridine hydrochloride (4-Picolylchloride hydrochl
  • 4-Picolyl chloride hydrochloride,97%
  • 4-Picolyl chloride h
  • 4-Picolyl chloride hydrochloride, 97% 10GR
  • 4-(CHLOROMETHYL)-PYRIDINIUM CHLORIDE FOR
CAS:
1822-51-1
MF:
C6H6ClN.ClH
MW:
164.03
EINECS:
217-350-7
Product Categories:
  • Pyridinium Compounds
  • blocks
  • Pyridines
  • Halides
  • Heterocycles
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Pyridines derivates
  • Heterocyclic Compounds
  • john's
Mol File:
1822-51-1.mol
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4-(Chloromethyl)pyridine hydrochloride Chemical Properties

Melting point:
166-173 °C(lit.)
storage temp. 
Inert atmosphere,2-8°C
solubility 
soluble in DMSO, Methanol
form 
Fine Crystalline Powder
color 
Yellow to orange
Water Solubility 
750 g/L (20 ºC)
Sensitive 
Hygroscopic
BRN 
3689154
CAS DataBase Reference
1822-51-1(CAS DataBase Reference)
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Safety Information

Hazard Codes 
C,Xi
Risk Statements 
34-4-22-36/37/38
Safety Statements 
26-36/37/39-45-36
RIDADR 
UN 3261 8/PG 3
WGK Germany 
3
3-10
Hazard Note 
Corrosive
HazardClass 
8
PackingGroup 
III
HS Code 
29333999

MSDS

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4-(Chloromethyl)pyridine hydrochloride Usage And Synthesis

Chemical Properties

YELLOW TO ORANGE FINE CRYSTALLINE POWDER

Uses

It finds its application as a reagent for protection of carboxyl termini of peptides as 4-picolyl esters, providing a polar 'handle' which aids in separation and purification of the peptide. The group can be introduced in the presence of a base, e.g. tetramethylguanidine, is stable to acid-catalyzed removal of Cbz protecting group and can be removed by base, Na in liquid ammonia or catalytic hydrogenolysis. It is also applied in conjunction with Amberlyst?15 resin in peptide synthesis. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.

Purification Methods

Purify it by recrystallisation from EtOH or EtOH/dry Et2O. It melts between 171o and 175o, and the clear melt resolidifies on further heating at 190o and turns red to black at 280o but does not melt again. The picrate-hydrochloride (prepared in EtOH) has m 146-147o. The free base is an oil. [Mosher & Tessieri J Am Chem Soc 73 4925 1951, Beilstein 20 III/IV 2752.]

4-(Chloromethyl)pyridine hydrochloride Preparation Products And Raw materials

Preparation Products

4-(Chloromethyl)pyridine hydrochlorideSupplier

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