2,6-Pyridinedicarboxylic acid monomethyl ester Chemical Properties

Melting point:

144-146°C

Boiling point:

393°C

Density 

1.361±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

soluble in Methanol

form 

powder to crystal

pka

3.27±0.10(Predicted)

color 

White to Almost white

InChI

InChI=1S/C8H7NO4/c1-13-8(12)6-4-2-3-5(9-6)7(10)11/h2-4H,1H3,(H,10,11)

InChIKey

VWIOMFMPIVMLIR-UHFFFAOYSA-N

SMILES

C1(C(OC)=O)=NC(C(O)=O)=CC=C1

CAS DataBase Reference

7170-36-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

HS Code 

2933399990

2,6-Pyridinedicarboxylic acid monomethyl ester Usage And Synthesis

Physical properties

White or off white powder
    

Uses

2,6-Pyridinedicarboxylic Acid Monomethyl Ester can be used as chemical scavengers.

Synthesis Reference(s)

Synthetic Communications, 25, p. 739, 1995 DOI: 10.1080/00397919508011411

Synthesis

To a solution of Dimethyl 2,6-pyridinedicarboxylate (10.0 g, 51.2 mmol) in MeOH (300 mL) was added KOH (2.89 g, 51.2 mmol) and themixture was stirred overnight at rt. After the removal of the solvent, the residue was diluted with water. Theaqueous layer was washed with AcOEt and acidified with conc. HCl aq, and then the mixture was extracted withthe solution of CHCl3/isopropanol (3/1 (v/v)). The organic layer were dried over MgSO4 and concentrated invacuo to give 2,6-Pyridinedicarboxylic acid monomethyl ester (8.17 g, 87 percent) as a white solid.

References

[1] Synthetic Communications, 1995, vol. 25, # 5, p. 739 - 742
[2] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 15, p. 3486 - 3489
[3] Tetrahedron, 1997, vol. 53, # 37, p. 12405 - 12414
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 17, p. 7267 - 7283
[5] Journal of Medicinal Chemistry, 2018, vol. 61, # 14, p. 6400 - 6400

2,6-Pyridinedicarboxylic acid monomethyl ester (7170-36-7)Related Product Information

• Tris(trimethylsilyl)phosphate
• DIPIPERIDINOMETHANE
• Methyl acrylate
• 3,4-Pyridinedicarboxylic acid
• Quinolinic acid
• Methyl dihydrojasmonate
• 2,5-PYRIDINEDICARBOXYLIC ACID
• 3,5-Pyridinedicarboxylic acid
• Pyridine-2,6-dicarboxylic acid
• Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
• dimethyl 4-chloropyridine-2,6-dicarboxylate
• Diethyl 2,6-pyridinedicarboxylate
• Dimethyl 2,6-Pyridinedicarboxylate
• (R)-(-)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid Monomethyl Ester
• Diethyl 4-bromopyridine-2,6-dicarboxylate
• [4,4'-BIPYRIDINE]-2,2',6,6'-TETRACARBOXYLIC ACID TETRAETHYL ESTER
• Diethyl 4-ethoxy-2,6-pyridinedicarboxylate
• Diethyl 4-iodo-2,6-pyridinedicarboxylate