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BLASTICIDIN S HYDROCHLORIDE

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BLASTICIDIN S HYDROCHLORIDE Basic information

Product Name:
BLASTICIDIN S HYDROCHLORIDE
Synonyms:
  • BLASTICIDINE S HYDROCHLORIDE
  • BLASTICIDIN S HCL
  • BLASTICIDIN S HYDROCHLORIDE
  • BLASTICIDIN S, HYDROCHLORIDE, STREPTOMYCES GRISEOCHROMOGENES
  • Blasticidine S hydrochloride,Blasticidin S
  • (S)-4-[[3-amino-5-[(aminoiminomethyl)methylamino]-1-oxopentyl]amino]-1-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,2,3,4-tetradeoxy-β-D-erythro-Hex-2-enopyranuronic acid,monohydrochloride
  • Blasticidine S HCl
  • Blasticidine S hydrochloride solution
CAS:
3513-03-9
MF:
C17H27ClN8O5
MW:
458.9
Product Categories:
  • Inhibitors
  • antibiotic
Mol File:
3513-03-9.mol
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BLASTICIDIN S HYDROCHLORIDE Chemical Properties

Melting point:
224-225 °C (decomp)
storage temp. 
−20°C
solubility 
Soluble in Water (greater than 25 mg/ml)
form 
Liquid
color 
White
Water Solubility 
Soluble in water. Insoluble in organic solvents.
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
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Safety Information

Hazard Codes 
T+
Risk Statements 
28
Safety Statements 
28-36/37-45
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
1-10
HazardClass 
6.1
HS Code 
29349990

MSDS

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BLASTICIDIN S HYDROCHLORIDE Usage And Synthesis

Description

Blasticidin S HCl (3513-03-9) is a peptidyl nucleoside antibiotic inhibiting protein synthesis in bacteria and eukaryotes.1?Inhibits translation by trapping deformed tRNA on the ribosome.1?The ABC-type transporter NppA1A2BCD is required for uptake of blasticidin S and other peptidyl nucleoside antibiotics in?Pseudomonas aeruginosa?PA14.2?Selection agent for bis, bsr and bsd transformed cells.3,4

Chemical Properties

White powder

Uses

Inhibits protein synthesis and induces apoptosis. Used to study protein synthesis at the level of peptide bond formation.

Uses

Blasticidin S hydrochloride is used to inhibit protein synthesis in prokaryotic and eukaryotic organisms. It also induces apoptosis.

Uses

Blasticidin S hydrochloride is a salt of blasticidin S, an amphoteric nucleoside produced by several species of Streptomyces, first reported in the late 1950s. Blasticidin S hydrochloride was originally isolated fby acetone precipitation. For historical reasons only the salt has been routinely available to researchers. Both the salt and free base are freely water soluble. Blasticidin S is an antifungal agent with particularly potent activity against the rice pathogen, Piricularia oryzae, for which it was used commercially for some time in Japan. Blasticidin S inhibits protein synthesis and is active against bacteria, tumour cell lines and nematodes. More recently, blasticidin S has been used as a marker for strain manipulations.

General Description

Nucleoside antibiotic that specifically inhibits protein synthesis in both prokaryotes and eukaryotes. Suitable for selection of cells carrying plasmids conferring blasticidin resistance. Blasticidin resistance is conferred by the blasticidin S deaminase gene (bsr) that converts blastisidin S to a nontoxic deaminohydroxy derivative.

References

1) Svidritskiy?et al., (2013),?Blasticidin S inhibits translation by trapping deformed tRNA on the ribosome;?Proc. Natl. Acad. Sci. USA?110?12283 2) Pletzer?et al.?(2015),?The Pseudomonas aeruginosa PA14 ABC Transporter NppA1A2BCD is Required for Uptake of Peptidyl Nucleoside Antibiotics; J. Bacteriol.?197?2217 3) Asada?et al.?(2015),?Transfection of Babesia bovis by Double Selection with WR99210 and Blasticidin-S and Its Application for Functional Analysis of Thioredoxin Peroxidase-1; PLoS One,?10?e0125993 4) Garg and Qadri (2010),?Hemoglobin transforms anti-inflammatory Salmonella typhi virulence polysaccharide into a TLR-2 agonist; J. Immunol.?184?5980

BLASTICIDIN S HYDROCHLORIDESupplier

Beijing Solarbio Science & Tecnology Co., Ltd. Gold
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010-40096860 4009686088
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Shanghai Jizhi Biochemical Technology Co. Ltd. Gold
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400-400-9004166 18017137653
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Sinopharm Chemical Reagent Co,Ltd.
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Dalian Meilun Biotech Co., Ltd.
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0411-62910999 13889544652
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Guangzhou Isun Pharmaceutical Co., Ltd
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020-39119399 18927568969
Email
isunpharm@qq.com