(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]-N-(1,3-dihydroxypropan-2-yl)hept-5-enamide Chemical Properties

Boiling point:

749.4±60.0 °C(Predicted)

Density 

1.330±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 30 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml

pka

13.43±0.20(Predicted)

(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]-N-(1,3-dihydroxypropan-2-yl)hept-5-enamide Usage And Synthesis

Description

2-arachidonyl glycerol (2-AG) exhibits cannabinoid (CB) agonist activity at the CB₁ receptor, is an important endogenous monoglyceride species, and is thus considered to be the natural ligand for the CB₁ receptor. 2-AG can also be metabolized by cyclooxygenase-2 and specific prostaglandin H₂ (PGH₂) isomerases to form PG 2-glyceryl esters. Fluprostenol serinol amide (Flu-SA) is a stable analog of PGF_2α 2-glyceryl ester that has much greater stability. The biological activity of Flu-SA has not yet been determined.

Definition

ChEBI: Fluprostenol serinol amide is a prostanoid.

(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]-N-(1,3-dihydroxypropan-2-yl)hept-5-enamide(1176658-85-7)Related Product Information

• 9-KETO FLUPROSTENOL
• 5-Heptenoic acid, 7-[(1S,2S,3S,5R)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-4-[3-(trifluoroMethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-, 1-Methylethyl ester, (5Z)-
• (+)-Fluprostenol
• 15(S)-FLUPROSTENOL
• 9-keto Fluprostenol isopropyl ester
• (Z)-7-[(1R)-3α,5α-Dihydroxy-2β-[(E,R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]cyclopentan-1α-yl]-5-heptenoic acid methyl ester
• 11-KETO FLUPROSTENOL