Meisoindigo Chemical Properties

Melting point:

236-237°C

Boiling point:

482.0±45.0 °C(Predicted)

Density 

1.381±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

insoluble in H2O; insoluble in EtOH; ≥25.85 mg/mL in DMSO with ultrasonic

form 

powder to crystal

pka

11.62±0.20(Predicted)

color 

Orange to Brown to Dark red

Safety Information

HS Code 

2933.79.1500

Meisoindigo Usage And Synthesis

Description

Meisoindigo is a derivative of indirubin that has anticancer activity. It inhibits the growth of NB4, HL-60, and U937 leukemia and primary acute myeloid leukemia (AML) cells when used at concentrations of 5 and 10 μM. It also halts the cell cycle at the G₀/G₁ phase and induces apoptosis in leukemia cell lines and primary AML cells, induces myeloid differentiation, and potentiates the effects of cytarabine and idarubicin . Meisoindigo (10 μM) also induces apoptosis, decreases adherence, and decreases the expression of vascular cell adhesion molecule-1 (VCAM-1) in ECV304 human vein endothelial cells. Meisoindigo (50-150 mg/kg per day) decreases spleen size in an HL-60 mouse xenograft model of AML in a dose-dependent manner.

Chemical Properties

mp 236-237°C

Uses

Meisoindigo is a 5-HT3 receptor antagonist prevents acute nausea and vomiting associated with emetogenic cancer chemotherapy

Uses

Meisoindigo shows strong anti-proliferation effect against gemcitabine-resistant Pancreatic ductal adenocarcinoma (PDACs).

References

[1] lee cc, lin cp, lee yl, wang gc, cheng yc, liu he. meisoindigo is a promising agent with in vitro and in vivo activity against human acute myeloid leukemia. leuk lymphoma. 2010 may;51(5):897-905.

Meisoindigo(97207-47-1)Related Product Information

• 4-Methyl-2-pentanone
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• 1-(2,6-Dichlorophenyl)indolin-2-one
• Basic Violet 1
• Methyl tetrahydrophthalic anhydride
• Methanol
• Mesotrione
• Methyl acrylate
• Acetonitrile
• cis-Octahydro-isoindole
• Paraquat dichloride
• Methylparaben
• Tetramethylammonium hydroxide
• Kresoxim-methyl
• Methyl
• 2-Butanone
• Indole
• Meisoindigo