3-Morpholinobenzaldehyde Chemical Properties

Melting point:

68 °C

Boiling point:

357.9±37.0 °C(Predicted)

Density 

1.163±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

solid

pka

3.80±0.40(Predicted)

color 

Yellow

Safety Information

Hazard Codes 

Xn

Risk Statements 

21/22-36/37/38

Safety Statements 

22-26-36/37/39

Hazard Note 

Harmful

HS Code 

2913000090

3-Morpholinobenzaldehyde Usage And Synthesis

Uses

3-Morphyrinylbenzaldehyde can be used as a pharmaceutical synthesis intermediate.

Synthesis

To a 500 mL round-bottomed flask was added 3-bromobenzaldehyde (6.44 g, 35.0 mmol, 1.00 eq.), morpholine (9.13 g, 105 mmol, 3.00 eq.), tris(dibenzylideneacetone)dipalladium (1.81 g, 1.75 mmol, 0.05 eq.), dicyclohexyl(2',6'-diisopropoxybiphenyl-2-yl)phosphine ( 3.26 g, 7.00 mmol, 0.20 equiv), cesium carbonate (34.2 g, 105 mmol) under nitrogen, 3.00 equiv), toluene (100 mL). The resulting solution was stirred overnight at 90??C and quenched with water (50 mL). The resulting solution was extracted with dichloromethane (3 x 200 mL), the organic layers were combined, washed with brine (3 x 100 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was chromatographed on a silica gel column with ethyl acetate/petroleum ether (3/17) to give 3-morpholino benzaldehyde (2.10 g, 32% yield) as a yellow oil.

3-Morpholinobenzaldehyde(446866-87-1)Related Product Information

• Moroxydine hydrochloride
• Moroxydine
• Tridemorph
• Dimethomorph
• 3-MORPHOLINOBENZOIC ACID
• 2-MORPHOLINOBENZALDEHYDE
• 4-MORPHOLINOBENZALDEHYDE,4-Morpholinobenzaldehyde, N-(4-formylphenyl)morpholine
• 5-MORPHOLINO-2-NITROBENZENECARBOXAMIDE
• 1-(3-MORPHOLIN-4-YLPHENYL)ETHANONE
• 4-CHLORO-3-MORPHOLIN-4-YL-BENZOIC ACID
• Methyl 3-morpholin-4-yl-benzoate
• 4-METHYL-3-MORPHOLIN-4-YL-BENZOIC ACID
• 1-(2-AMINO-5-MORPHOLINOPHENYL)-1-ETHANONE
• flumorph
• 3-Morpholinobenzaldehyde
• 4-CHLORO-3-MORPHOLIN-4-YL-BENZOIC ACID HYDRAZIDE
• 3-MORPHOLIN-4-YL-BENZOIC ACID ETHYL ESTER
• 4-METHYL-3-MORPHOLIN-4-YL-BENZOIC ACID METHYL ESTER