2-Amino-4-(trifluoromethyl)pyrimidine Chemical Properties

Melting point:

175-177°C

Boiling point:

260.7±50.0 °C(Predicted)

Density 

1.460±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

powder to crystal

pka

1.90±0.10(Predicted)

color 

White to Light yellow

λmax

308nm(EtOH aq.)(lit.)

CAS DataBase Reference

16075-42-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,N,T

Risk Statements 

36/37/38-50-43-36-25

Safety Statements 

26-36/37/39-61-45-36/37

RIDADR 

2811

WGK Germany 

3

HazardClass 

IRRITANT

PackingGroup 

Ⅲ

HS Code 

29335990

MSDS

• Language:English Provider:ALFA

2-Amino-4-(trifluoromethyl)pyrimidine Usage And Synthesis

Chemical Properties

White to brown powder

Synthesis

Step 2: To a solution of compound [63] (22.8 g, 2.4 mmol, 1 eq.) in anhydrous ethanol (100 mL), NaOH granules (9.55 g, 238 mmol, 1 eq.) were added and the reaction mixture was stirred for 16 h at room temperature. Subsequently, a solution of compound [84] was slowly added through a dropping funnel over a period of 2 hours. After addition, the reaction mixture was continued to be stirred for 2 hours. Upon completion of the reaction, the solvent was removed by evaporation and the residue was dissolved in water (500 mL) with vigorous stirring for 2 hours, followed by standing at room temperature overnight. The precipitate precipitated was collected by filtration and dried under vacuum to give compound [85] as a light yellow solid (20.6 g, 53% yield).

References

[1] Patent: WO2014/16849, 2014, A2. Location in patent: Page/Page column 117

2-Amino-4-(trifluoromethyl)pyrimidine(16075-42-6)Related Product Information

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