2'-O-Methyluridine Chemical Properties

Melting point:

154-156°C

Density 

1.53±0.1 g/cm3(Predicted)

storage temp. 

Inert atmosphere,2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

9.39±0.10(Predicted)

form 

Powder

color 

White to Off-white

λmax

261nm(MeOH)(lit.)

CAS DataBase Reference

2140-76-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

T+

Risk Statements 

26/27/28

Safety Statements 

24/25

HS Code 

29389090

2'-O-Methyluridine Usage And Synthesis

Description

2'-O-Methyluridine is an analog of uridine and has been shown to have antiviral and anticancer properties. 2'-O-Methyluridine inhibits protein synthesis by competing with uridine for the active site of the enzyme ribonucleotide reductase, which converts ribonucleotides to dNMPs. This compound also inhibits RNA synthesis by disrupting the pairing of adenine and cytosine residues in RNA strands.

Chemical Properties

White Solid

Uses

Uridine analog. Used for preparation of antiviral nucleoside derivatives as inhibitors of subgenomic hepatitis C virus RNA replication.

Uses

Uridine analog. 2'-O-Methyluridine is used for preparation of antiviral nucleoside derivatives as inhibitors of subgenomic hepatitis C virus RNA replication.

Definition

ChEBI: A methyluridine that consists of uridine bearing a single methyl substituent located at position O-2' on the ribose ring.

2'-O-Methyluridine(2140-76-3)Related Product Information

• (Trifluoromethoxy)benzene
• Trifluridine
• Doxifluridine
• 2',3',5'-Tri-O-acetyluridine
• uridine diphosphate glucose {= UDP-glucose}
• Methyluridine
• 2',3',5'-TRI-O-BENZOYLURIDINE
• 2′,3′-O-Isopropylideneuridine
• 5-METHY-5-METHYLURIDINE,5-METHYL-2'-O-METHYLURIDINE,2'-O-METHYL-5-METHYLURIDINE
• 2'-O-Methyl-5'-O-DMT-Uridine
• 2'-OMe-U-CE Phosphoramidite
• DMT-2'O-Methyl-rU Phosphoramidite
• 2,2'-ANHYDRO-5-METHYLURIDINE,2,2'β-Oxy-2-deoxo-2,3-didehydro-2'-deoxy-5-methyluridine,O2,2'-Anhydro-5-methyluridine
• 2'-DEOXY-2'-FLUORO-5-METHYLURIDINE
• 3-METHYLURIDINE
• 2'-C-Methyluridine
• 3',5'-DI-O-BENZOYL-5-FLUORO-2'-O-METHYLURIDINE
• 5'-O-(DMT)-5-IODO-2'-O-METHYLURIDINE