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MOPSO

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MOPSO Basic information

Product Name:
MOPSO
Synonyms:
  • MOPSO
  • 3-(N-MORPHOLINO)-2-HYDROXY-1-PROPANESULFONIC ACID
  • 3-(N-MORPHOLINO)-2-HYDROXYPROPANESULFONIC ACID
  • 3-MORPHOLINO-2-HYDROXYPROPANESULFONIC ACID
  • 3-MORPHOLINO-2-HYDROXYPROPANESULPHONIC ACID
  • 4-Morpholinepropanesulfonicacid, b-hydroxy-
  • 2-HYDROXY-3-MORPHOLINOPROPANESULFONIC ACID
  • 2-HYDROXY-3-MORPHOLIN-4-YL-PROPANE-1-SULFONIC ACID
CAS:
68399-77-9
MF:
C7H15NO5S
MW:
225.26
EINECS:
269-989-6
Product Categories:
  • Buffer
  • Biochemistry
  • Good's Buffers
Mol File:
68399-77-9.mol
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MOPSO Chemical Properties

Melting point:
275-280 °C (dec.)
Density 
1.416±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
H2O: 0.5 M at 20 °C, clear
form 
Crystalline Powder
pka
pK1:6.75 (37°C)
color 
White
PH Range
6.2 - 7.6
Odor
Odorless
Water Solubility 
Water solubility under desired conditions ca.112,6 g/L at 20°C.
BRN 
1109697
InChI
InChI=1S/C7H15NO5S/c9-7(6-14(10,11)12)5-8-1-3-13-4-2-8/h7,9H,1-6H2,(H,10,11,12)
InChIKey
NUFBIAUZAMHTSP-UHFFFAOYSA-N
SMILES
C(N1CCOCC1)C(O)CS(O)(=O)=O
CAS DataBase Reference
68399-77-9(CAS DataBase Reference)
EPA Substance Registry System
4-Morpholinepropanesulfonic acid, .beta.-hydroxy- (68399-77-9)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
1
TSCA 
Yes
HS Code 
29349990

MSDS

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MOPSO Usage And Synthesis

Description

MOPSO Free Acid is a zwitterionic aminosulfonate buffer with a similar structure to MOPS and a useful pH range of 6.5 - 7.9. It may be used as a buffer component in various biological applications including DNA gel electrophoresis. It has been found that MOPSO buffer combined excellent pH stabilization at pH 7·00 and limited color alteration by testing the color changes of raw sugar solutions so that MOPSO buffer and three glass-fiber filters in series can be used to reduce the effect of pH and turbidity on color measurement of raw sugar solution[1]. The activity of the endo-α-D-mannosidase enzyme in MOPSO buffers at pH 7.0 is increased very much over buffers like HEPES or HEPPS. This buffer also has been employed as a buffer component of charcoal yeast extract medium[2]. However, morpholine family buffers (MES, MOPS, and MOPSO) have been reported to interact with the trivalent metal ions Cr3+ and Fe3+. Therefore, extensive testing is required before using MAPSO.

Chemical Properties

white crystalline powder

Uses

MOPSO is a buffer that works in the 6-7 pH range. Used in pharmaceutical synthesis.

Uses

MOPSO is a biological buffer also referred to as a second generation “Good′s” buffer which displays improved solubility compared to traditional “Good′s” buffers. The pKa of MOPSO is 6.9 which make it an ideal candidate for buffer formulations which require a pH slightly below physiological to maintain a stable environment in solution. MOPSO is considered to be non-toxic to culture cell lines and provides high-solution clarity.

MOPSO can be used in cell culture media, biopharmaceutical buffer formulations (both upstream and downstream) and diagnostic reagents.

Definition

ChEBI: 3-(n-morpholino)-2-hydroxypropanesulfonic acid is a member of morpholines.

References

[1] Ahmedna M, et al. Use of filtration and buffers in raw sugar colour measurements. Journal of the Science of Food and Agriculture, 1997; 75: 109-116.   
[2] Taha M, et al. Interactions of Biological Buffers with Macromolecules: The Ubiquitous “Smart” Polymer PNIPAM and the Biological Buffers MES, MOPS, and MOPSO. Macromolecules, 2011; 44: 8575–858.

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