Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid Basic information
- Product Name:
- Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
- Synonyms:
-
- Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,(bR)-
- (R)-Sitagliptin N-Boc-Acid IMpurity
- Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid (3R)-N-(tert-Butoxycarbonyl)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid
- Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid, >=99%
- (3R)-N-Boc-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid
- (3R)-N-(tert-Butoxycarbonyl)-3-aMino-4-(2,4,5-trifluorophenyl)-butanoic acid- Boc-(R)-3-AMino-4-(2,4,5-trifluorophenyl) butanoic acid (BOC acid)
- [[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-(R)-benzenebuta
- BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID
- CAS:
- 486460-00-8
- MF:
- C15H18F3NO4
- MW:
- 333.31
- EINECS:
- 691-120-8
- Product Categories:
-
- B-Amino
- Mol File:
- 486460-00-8.mol
Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid Chemical Properties
- Melting point:
- 136-138℃
- Boiling point:
- 443.1±45.0 °C(Predicted)
- Density
- 1.292±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 4.30±0.10(Predicted)
- color
- White to Off-White
Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid Usage And Synthesis
Physical Form
White to Yellow Solid
Description
Boc-(R) -3-amino-4 -(2,4, 5-trifluorophenyl) butyric acid is an important intermediate for the preparation of sitagliptin. Sitagliptinphosphate is the first dipeptidase -IV(dpp-4) inhibitor approved by FDA in 2006. It is used for the treatment of type II diabetes mellitus. It has obvious hypoglycemic effect when used alone or in combination with metformin and pioglitazone, and it is safe to take, well tolerated, with few adverse reactions.
Uses
(R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic Acid has been used as a reactant for the preparation of dipeptidyl peptidase-4 (DPP4) inhibitors for the treatment of type 2 diabetes, such as sitagliptin.
Synthesis
(R)-β-tert-butoxycarbonylamino-2,4,5-trifluorophenylbutyric acid ethyl ester could used as a starting material and followed by adding Methanol and LiOHH2O as reaction reagents. Adding dichloromethane to the concentrate and adjust the pH to 2 with 2N HCl. Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid could be obtained through further purification.
Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acidSupplier
- Tel
- 010-84663308 15510081019;
- rndjh@sinopharm.com
- Tel
- 0512-62956066 18112603058
- kendoll@cqpharm.com
- Tel
- 0556-5800026 17709662922
- melrose@worldpharma.cn
- Tel
- 0576-88808091 13958565781
- shuang.lin@zhenleichem.com
- Tel
- 010-68862197 13810598707
- sales@huikangchem.com
Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid(486460-00-8)Related Product Information
- 2-Deoxy-L-ribose
- Sebacic acid
- Butyraldehyde
- ETHYLENE OXIDE
- BOC-(S)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID
- BOC-(R)-3-AMINO-4-(3-FLUORO-PHENYL)-BUTYRIC ACID
- (R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid
- BOC-(R)-3-AMINO-4-(4-FLUORO-PHENYL)-BUTYRIC ACID
- BOC-(R)-3-AMINO-4-(3,4-DIFLUORO-PHENYL)-BUTYRIC ACID
- Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate
- BOC-(R)-3-AMINO-4-(2-FLUORO-PHENYL)-BUTYRIC ACID
- Sitagliptin
- Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,Methylester,(bR)-
- (R)-methyl 3-acetamido-4-(2,4,5-trifluorophenyl)butanoate
- 2,4,5-TRIFLUOROBENZYL CHLORIDE
- Sitagliptin Impurity 34
- 2-CHLOROMETHYL-5-TRIFLUOROMETHYL-[1,3,4]OXADIAZOLE
- ethyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate