ChemicalBook > Product Catalog > API > Digestive system drugs > Laxatives and Antidiarrheal Medicines > 3,3-BIS(P-HYDROXYPHENYL)OXINDOLE
3,3-BIS(P-HYDROXYPHENYL)OXINDOLE
3,3-BIS(P-HYDROXYPHENYL)OXINDOLE Basic information
- Product Name:
- 3,3-BIS(P-HYDROXYPHENYL)OXINDOLE
- Synonyms:
-
- 3,3-Bis(4-hydroxyphenyl)indoline-2-one
- 3,3-bis(4-hydroxyphenyl)-1H-indol-2-one
- 3,3-Bis(4-Hydroxsyphenyl)-2(3H)-Indolone
- 3,3-Bis(4-hydroxyphenyl)-1,3-dihydro-2H-indol-2-one
- recolon
- veripaque
- 3,3-bis(4-hydroxyphenyl)indolin-2-one
- 3,3-BIS(4-HYDROXYPHENYL)-2-INDOLINONE
- CAS:
- 125-13-3
- MF:
- C20H15NO3
- MW:
- 317.34
- EINECS:
- 204-728-1
- Mol File:
- 125-13-3.mol
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3,3-BIS(P-HYDROXYPHENYL)OXINDOLE Chemical Properties
- Melting point:
- 260-261 °C
- Boiling point:
- 562.9±50.0 °C(Predicted)
- Density
- 1.352±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 28 mg/mL (88.23 mM)
- form
- Solid
- pka
- 9.42±0.30(Predicted)
- color
- White to off-white
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3,3-BIS(P-HYDROXYPHENYL)OXINDOLE Usage And Synthesis
Chemical Properties
Crystallization. Melting point>260℃.
Uses
Oxyphenisatine is a diphenolic laxative and it’s prodrug Oxyphenisatine acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468 by inducing multifaceted cell starvation response, which ultimately induces programmed cell death.
Definition
ChEBI: Oxyphenisatine is a member of indoles.
in vivo
Toxicity studies demonstrate that mice tolerate IP administration of OXY at 300 mg/kg once daily or 200 mg/kg twice daily. Administration of OXY at 300 mg/kg IP once daily for 10 days results in significantly smaller tumors from day 33 to day 52[1].
3,3-BIS(P-HYDROXYPHENYL)OXINDOLESupplier
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