Methyl pyruvate Chemical Properties

Melting point:

-22 °C

Boiling point:

134-137 °C (lit.)

Density 

1.13 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.404(lit.)

Flash point:

103 °F

storage temp. 

2-8°C

solubility 

ethanol: soluble1.1g/10 mL, clear, colorless to almost colorless

form 

liquid

color 

Yellow

Water Solubility 

Soluble in chloroform, methanol, ether, alcohol. Slightly soluble in water.

Merck 

14,8021

BRN 

1361953

LogP

-0.159 (est)

CAS DataBase Reference

600-22-6(CAS DataBase Reference)

NIST Chemistry Reference

Propanoic acid, 2-oxo-, methyl ester(600-22-6)

Safety Information

Hazard Codes 

Xi,F

Risk Statements 

10

Safety Statements 

23-24/25-16

RIDADR 

UN 3272 3/PG 3

WGK Germany 

3

F 

10-21

HazardClass 

3

PackingGroup 

III

HS Code 

29183000

MSDS

• Language:English Provider:Methyl pyruvate
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Methyl pyruvate Usage And Synthesis

Chemical Properties

Methyl pyruvate is a clear, light yellow, and flammable liquid.

Uses

Methyl Pyruvate acts as a potent secretagogue used in the study of stimulus-secretion coupling. Also used in the preparation of quinoxalines as dual phoosphodiesterase 2/10 (PDE2/10) inhibitors. It increases free calcium ion concentration in the cytosol of pancreatic cells. It is used in the preparation of dimethyl 2,3-dimethylenebutanedioate.

Uses

Methyl pyruvate may be used to investigate the adsorption and reactivity of methyl pyruvate on Pt{111}. It may be used in the preparation of dimethyl 2,3-dimethylenebutanedioate.

Definition

ChEBI: Methyl pyruvate is a pyruvate ester resultinf grom the formal condensation of the carboxy group of pyruvic acid with the hydroxy group of methanol. It is a pyruvate ester and a methyl ester. It derives from a pyruvic acid.

Preparation

Methyl pyruvate has been prepared from the silver salt of pyruvic acid and methyl iodide; from the free acid, by the ethanol-vapor method without a catalyst, by azeotropic removal of the water produced by the reaction of methanol in the presence of p-toluenesulfonic acid (the present method), and by refluxing with methanol in ethylene dichloride using ethanesulfonic acid as a catalyst (73% yield). Pyruvic esters have also been prepared by the catalytic dehydrogenation of lactic acid esters and by the oxidation of ethyl lactate with potassium permanganate.
DOI: 10.15227/orgsyn.024.0072

General Description

Methyl pyruvate is a pyruvic ester. Surface conditions during Pt/silica EUROPT-1 modified by cinchonidine catalyzed by enantioselective hydrogenation of methyl pyruvate to R-(+)-methyl lactate were investigated. Enantioselective hydrogenation of methyl pyruvate over finely dispersed polyvinylpyrrolidone-stabilized and the corresponding alumina-supported iridium clusters modified with cinchonidine was studied. The molecular orientation and conformation of methyl pyruvate on Ni(111) surface has been investigated in the temperature range 105-220K. Methyl pyruvate is reported to stimulate insulin secretion in vitro and in vivo.

Methyl pyruvate(600-22-6)Related Product Information

• Methylparaben
• Kresoxim-methyl
• Bensulfuron methyl
• Ethyl pyruvate
• EC 4.1.1.1
• Methyl acrylate
• Calcium pyruvate
• METHYL THIOPHENE-2-CARBOXYLATE
• Thiophanate-methyl
• Pyruvic acid
• Creatine pyruvate
• PYRUVATE DEHYDROGENASE
• EC 2.7.1.40
• Methyl acetate
• Sodium pyruvate
• Phosphoenolpyruvate carboxylase
• Methylglyoxal
• Methyl