2-(4-Chlorophenyl)thiazole-5-carbaldehyde Chemical Properties

Boiling point:

377.6±48.0 °C(Predicted)

Density 

1.388±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

0.14±0.10(Predicted)

Safety Information

Risk Statements 

43

Safety Statements 

36/37

2-(4-Chlorophenyl)thiazole-5-carbaldehyde Usage And Synthesis

Synthesis

Step 1. Synthesis of 2-(4-chlorophenyl)-1,3-thiazole-5-carbaldehyde. 4-Chlorobenzamide (5 g, 29.1 mmol), magnesium bicarbonate pentahydrate (7.06 g, 14.55 mmol) and 2-chloromalonaldehyde (4.65 g, 43.65 mmol) were added to a flask and the reaction was stirred for 3 hr at 60 °C under nitrogen protection. Upon completion of the reaction, the reaction mixture was allowed to pass through a silica plug for rapid column chromatography and washed with ethyl acetate. The solvent was removed by concentration under reduced pressure to afford the target product 2-(4-chlorophenyl)-1,3-thiazole-5-carbaldehyde (6 g, 92% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 10.06 (s, 1H), 8.43 (s, 1H), 7.99-7.96 (m, 2H), 7.49-7.46 (m, 2H).

References

[1] Patent: WO2004/58761, 2004, A1. Location in patent: Page 37-38
[2] Patent: WO2011/12862, 2011, A1. Location in patent: Page/Page column 102; 109

2-(4-Chlorophenyl)thiazole-5-carbaldehyde(721920-84-9)Related Product Information

• Fosthiazate
• Chlorodimethylphenylsilane
• Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT)
• Benzothiazole
• Triphenylmethyl Chloride
• ETHYL 2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE
• 1-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-5-YL]-3-(DIMETHYLAMINO)-2-PROPEN-1-ONE
• 2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLIC ACID
• ETHYL 2-(4-CHLOROPHENYL)-4-HYDROXY-1,3-THIAZOLE-5-CARBOXYLATE
• METHYL 2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE
• ETHYL 2-(2,4-DICHLOROPHENYL)-4-HYDROXYTHIAZOLE-5-CARBOXYLATE
• 2-(4-Chlorophenyl)thiazole-5-carbaldehyde
• [2-(4-CHLOROPHENYL)-1,3-THIAZOL-5-YL](PHENYL)METHANONE
• [1,1'-BIPHENYL]-4-YL[2-(4-CHLOROPHENYL)-1,3-THIAZOL-5-YL]METHANONE
• 3-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-5-YL]-3-OXOPROPANAL O-(2-[3-(TRIFLUOROMETHYL)PHENOXY]ETHYL)OXIME
• (4-BROMOPHENYL)[2-(4-CHLOROPHENYL)-1,3-THIAZOL-5-YL]METHANONE
• [2-(4-CHLOROPHENYL)-1,3-THIAZOL-5-YL](3,4-DICHLOROPHENYL)METHANONE
• 2-(4-CHLOROPHENYL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE-5-CARBOXAMIDE