Isopropyl chloroacetate Chemical Properties

Boiling point:

149-150 °C(lit.)

Density 

1.096 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.419(lit.)

Flash point:

159 °F

form 

clear liquid

color 

Colorless to Almost colorless

Water Solubility 

SLIGHTLY SOLUBLE

CAS DataBase Reference

105-48-6(CAS DataBase Reference)

NIST Chemistry Reference

Chloroacetic acid isopropyl ester(105-48-6)

EPA Substance Registry System

Acetic acid, chloro-, 1-methylethyl ester (105-48-6)

Safety Information

Hazard Codes 

T

Risk Statements 

10-25-36/37/38

Safety Statements 

26-37/39-45-1/2

RIDADR 

UN 2947 3/PG 3

WGK Germany 

1

TSCA 

Yes

HazardClass 

3

PackingGroup 

III

HS Code 

29154000

MSDS

• Language:English Provider:(1-Methylethyl)-2-chloroacetate
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Isopropyl chloroacetate Usage And Synthesis

Chemical Properties

CLEAR COLOURLESS TO ALMOST COLOURLESS LIQUID

Uses

Isopropyl Chloroacetate is used as a reactant in the design, synthesis, and 3D-QSAR analysis of novel oxadiazolones as protoporphyrinogen oxidase inhibitors.

General Description

A clear colorless liquid. Flash point near 60°F. Boiling point near 200°F. Less dense than water. Vapors heavier than air. Used to make other chemicals.

Air & Water Reactions

Highly flammable. Soluble in water.

Reactivity Profile

Isopropyl chloroacetate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Health Hazard

TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Bromoacetates and chloroacetates are extremely irritating/lachrymators. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

Isopropyl chloroacetate(105-48-6)Related Product Information

• Isopropyl 2-cyanoacetate
• ISOPROPYL LAURATE
• Isopropyl palmitate
• Isopropyl alcohol
• Isopropyl acetate
• Titanium tetraisopropanolate
• Isopropyl myristate
• 2,2'-Thiobispropane
• Isopropyl bromoacetate
• Diisopropyl malonate
• Diisopropyl azodicarboxylate
• 2-Pyrrolidinecarbonitrile,1-acetyl-,(2S)-(9CI)
• Vildagliptin Impurity 6
• N-acetic acid-1-aMino-3-adaMantanol
• glycyl-L-ProlinaMide
• 2-Pyrrolidinecarboxamide,1-(hydroxyacetyl)-,(S)-(9CI)
• N-methylpyrrolidine-2-carboxamide
• Vildagliptin Impurity 38