4-Methoxypyridine N-oxide Chemical Properties

Melting point:

73-79 °C

Boiling point:

308.9±15.0 °C(Predicted)

Density 

1.09±0.1 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

pka

2.30±0.10(Predicted)

form 

powder to crystal

color 

White to Yellow to Orange

Sensitive 

Hygroscopic

λmax

282nm(CH3CN)(lit.)

BRN 

115212

InChI

InChI=1S/C6H7NO2/c1-9-6-2-4-7(8)5-3-6/h2-5H,1H3

InChIKey

BOFAIBPJCWFJFT-UHFFFAOYSA-N

SMILES

C1[N+]([O-])=CC=C(OC)C=1

CAS DataBase Reference

1122-96-9(CAS DataBase Reference)

NIST Chemistry Reference

Pyridine, 4-methoxy-1-oxide-(1122-96-9)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39-24/25-37

WGK Germany 

3

F 

3-10

HS Code 

29333990

MSDS

• Language:English Provider:4-Methoxypyridine 1-oxide
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-Methoxypyridine N-oxide Usage And Synthesis

Chemical Properties

Orange Solid

Uses

4-Methoxypyridine N-oxide is a heteroaromatic N-oxide used as a nucleophilic catalyst in oligonucleotide synthesis and free radical polymerization.

Synthesis

In a 25-mL round-bottomed two-necked flask, 4 mL of methanol was added, followed by 4-methoxypyridine (0.5 mmol, 54.6 mg), 30% H2O2 (6.0 eq., 0.3 mL), potassium carbonate (4.0 eq., 276.4 mg), and SO2F2 gas was introduced into the gas stream by using two straight pistons with straight bends and a hose to connect a balloon on one side. The reaction was carried out under sealed conditions with stirring for 20-40 min at room temperature of 23-32 ??C. After the reaction, the potassium carbonate solid was removed by filtration, dried with anhydrous sodium sulfate to remove water and filtered again, and the solvent was concentrated to obtain the crude product, which was finally isolated and purified by column chromatography to give 40.3 mg of 4-methoxypyridinium nitride in a yield of 65.4%.

4-Methoxypyridine N-oxide(1122-96-9)Related Product Information

• 4-Methylpyridine
• Magnesium oxide
• p-Anisidine
• 4-Methoxypyridine
• p-Anisaldehyde
• Propylene oxide
• Zinc oxide
• Cuprous oxide
• 3-Methoxybenzaldehyde
• 4-Methoxyphenylacetone
• Anisole
• (Trifluoromethoxy)benzene
• Pyridine-N-oxide
• NITRIC OXIDE
• ETHYLENE OXIDE
• Iron oxide
• (Diethoxymethyl)diphenylphosphine oxide
• 7-CHLORO-1,3-DIHYDRO-5-PHENYL-2H-1,4-BENZODIAZEPINE-2-ONE-4-OXIDE