KETANSERIN TARTRATE
KETANSERIN TARTRATE Basic information
- Product Name:
- KETANSERIN TARTRATE
- Synonyms:
-
- R 41468
- R 41468 TARTRATE SALT
- 3-(2-(4-(p-fluorobenzoyl)-1-piperidinyl)ethyl)-2,4(1h,3h)-quinazolinedionel
- 4(1h,3h)-quinazolinedione,3-(2-(4-(4-fluorobenzoyl)-1-piperidinyl)ethyl)-(
- kjk-945
- r-(r*,r*))-2,3-dihydroxybutanedioate(1:1)
- 3-[2-[4-(4-fluorobenzoyl)piperidino]ethyl]quinazoline-2,4(1H,3H)-dione [R-(R*,R*)]-tartrate
- KETANSERIN TARTRATE (R 41468) (SELECTIVE 5-HT2/5-HT1C SEROTONI
- CAS:
- 83846-83-7
- MF:
- C26H28FN3O9
- MW:
- 545.52
- EINECS:
- 281-062-8
- Product Categories:
-
- Serotonin
- Cardiovascular APIs
- Serotonin receptor
- Mol File:
- 83846-83-7.mol
KETANSERIN TARTRATE Chemical Properties
- Melting point:
- 183～186℃
- storage temp.
- 2-8°C
- solubility
- ethanol: 3.3mg/mL
- form
- solid
- color
- white
- Water Solubility
- Soluble to 10 mM in water
- CAS DataBase Reference
- 83846-83-7(CAS DataBase Reference)
Safety Information
- Hazard Codes
- T
- Risk Statements
- 25
- Safety Statements
- 22-36/37/39-45
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- VA1411195
- HazardClass
- 6.1
- HS Code
- 29335990
- Toxicity
- LD50 oral in rat: 129mg/kg
MSDS
- Language:English Provider:SigmaAldrich
KETANSERIN TARTRATE Usage And Synthesis
Description
Ketanserin is a potent antagonist of the serotonin (5-HT) receptor that is selective for 5-HT2 (IC50 = 6.3 nM; Ki = 2.1 nM). It has no activity at 5-HT1 receptors but does have activity at histamine type 1, α1-adrenergic, and dopamine receptors with Ki values of 10, 10, and 220 nM, respectively. Ketanserin induces dose-dependent inhibition of contractile responses to 5-HT in isolated rat caudal artery, canine basilar, carotid, coronary and gastrosplenic arteries, and canine gastrosplenic and saphenous veins. Ketanserin (10 mg/kg/day) significantly decreases blood pressure (BP), blood pressure variability (BPV), and hypertensive organ damage in spontaneously hypertensive rats. Formulations containing ketanserin have been used to treat hypertension in early-onset preeclampsia.
Uses
coccidiostat
Uses
Selective 5-HT2A serotonin receptor antagonist
Biological Activity
Selective 5-HT 2A serotonin receptor antagonist; can also be used to discriminate between 5-HT 1D and 5-HT 1B receptor subtypes.
Biochem/physiol Actions
Selective 5-HT2 serotonin receptor antagonist. Ketanserin significantly reduces nicotine self-administration in rats, supporting an unexpected involvement of serotonin in nicotine addiction.
storage
Room temperature
KETANSERIN TARTRATESupplier
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- 010-82848833 400-666-7788
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KETANSERIN TARTRATE(83846-83-7)Related Product Information
- 2-(4-BENZYLPIPERIDINO)-1-ETHANAMINE
- 4-BENZOYLPIPERIDINE HYDROCHLORIDE
- 4-(4'-Fluorobenzyl)piperidine
- Butanedioic acid,2,3-dihydroxy- (2R,3R)-, ammonium salt (1:)
- KETANSERIN TARTRATE
- BENZOYLUREA
- 4-(4-Fluorobenzoyl)piperidine
- N-(2-Aminoethyl)piperidine
- 1-(4-FLUORO-PHENYL)-BUTAN-1-ONE
- Benzoyleneurea
- Ketanserin
- 4'-Fluoropropiophenone
- 4-Benzylpiperidine
- 1-(4-FLUOROPHENYL)-2-METHYLPROPAN-1-ONE
- 5-Diethylamino-2-pentanone
- CHEMBRDG-BB 4013122
- 3,4-DIHYDROQUINAZOLIN-2(1H)-ONE
- 3,4-DIHYDRO-3-METHYL-2(1H)-QUINAZOLINONE