2-Ethoxybenzoic acid Chemical Properties

Melting point:

19.3-19.5 °C (lit.)

Boiling point:

174-176 °C/15 mmHg (lit.)

Density 

1.105 g/mL at 25 °C (lit.)

vapor pressure 

0.281Pa at 25℃

refractive index 

n20/D 1.54(lit.)

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

95% ethanol: soluble5%, clear, colorless to yellow

form 

Liquid

pka

pK1:4.21 (20°C)

Specific Gravity

1.105

color 

White or Colorless to Light yellow to Light orange

Water Solubility 

Soluble in water.

BRN 

2691039

LogP

1.295 at 25℃

CAS DataBase Reference

134-11-2(CAS DataBase Reference)

NIST Chemistry Reference

Benzoic acid, 2-ethoxy-(134-11-2)

EPA Substance Registry System

Benzoic acid, 2-ethoxy- (134-11-2)

Safety Information

Hazard Codes 

Xi,T

Risk Statements 

36/37/38-26-22

Safety Statements 

23-24/25-45-36/37-28-26

WGK Germany 

3

TSCA 

Yes

HazardClass 

IRRITANT

HS Code 

29189900

MSDS

• Language:English Provider:2-Ethoxybenzoic acid
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2-Ethoxybenzoic acid Usage And Synthesis

Chemical Properties

Pale yellow low melting solid

Uses

2-Ethoxybenzoic acid is used in thermally induced solvent-free reactions of triphenylbismuth with a series of thiols and carboxylic acids. It serves as an active component of dental cement. Further, it prevents the entry of root-canal pathogens into periapical regions.

General Description

2-Ethoxybenzoic acid is dental cement. It is root-end filling material and prevents the entry of root-canal pathogens into periapical regions.

Flammability and Explosibility

Not classified

Synthesis

The general procedure for the synthesis of 2-ethoxybenzoic acid from ethyl o-ethoxybenzoate was as follows: potassium tert-butoxide (10 g, 890 mmol) was added batchwise to a stirred solution of ethyl 2-ethoxybenzoate (10 g, 240 mmol) in dimethyl sulfoxide (40 mL). The reaction mixture was heated to 70 °C in a water bath and maintained at this temperature for 2 h. The progress of the reaction was monitored by thin layer chromatography (TLC) using hexane-ethyl acetate (8:2) as a spreading agent. Upon completion of the reaction, the reaction mixture was cooled to 10 °C and poured into ice water. Subsequently, the reaction mixture was acidified with 5% dilute hydrochloric acid. The precipitated solid was filtered and washed thoroughly with distilled water. The crude product was recrystallized in hexane (50 mL) to give a final off-white solid 2-ethoxybenzoic acid (7.6 g, 80% yield).

References

[1] Patent: US2006/167107, 2006, A1. Location in patent: Page/Page column 4
[2] Justus Liebigs Annalen der Chemie, 1922, vol. 429, p. 169
[3] Journal of the Chemical Society, Chemical Communications, 1992, # 11, p. 823 - 824

2-Ethoxybenzoic acid(134-11-2)Related Product Information

• 4-Ethoxyphenol
• 3,5-Dimethoxybenzoic acid
• Ethyl 2-(Chlorosulfonyl)acetate
• 3,4,5-Trimethoxy benzoic acid
• 2,3,4-Trihydroxybenzoic acid
• 2-Benzoylbenzoic acid
• 3,4-Dimethoxybenzoic acid
• Ethoxyquin
• 2-Ethoxybenzoyl chloride
• DIETHOXYMETHANE
• Salicylic acid
• Thiosalicylic acid
• 2-Nitrobenzoic acid
• 2,3-Dimethoxybenzoic acid
• o-Toluic acid
• 2,6-Dimethoxybenzoic acid
• 2-Iodobenzoic acid
• Hyaluronic acid