2-FLUORO-5-NITRO-3-PICOLINE Chemical Properties

Boiling point:

265.7±35.0 °C(Predicted)

Density 

1.357±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

pka

-4.17±0.20(Predicted)

CAS DataBase Reference

19346-46-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,C

Risk Statements 

36/37/38-34

Safety Statements 

26-36-45-36/37/39

HazardClass 

IRRITANT, IRRITANT-HARMFUL

HS Code 

2933399990

2-FLUORO-5-NITRO-3-PICOLINE Usage And Synthesis

Synthesis

2-Chloro-3-methyl-5-nitropyridine (15 g, 86.9 mmol, purchased from Maybridge Chemical Co.), potassium fluoride (12 g, 258 mmol), and tetraphenylphosphonium bromide (20 g, 47.7 mmol, purchased from Aldrich) were mixed in 200 mL of acetonitrile and the reaction was heated to reflux for 4 days. After completion of the reaction, the reaction mixture was diluted with ether (500 mL) and filtered, and the filtrate was concentrated to obtain the crude product. The crude product was ground with hot hexane (4 x 200 mL), the hexane solutions were combined and concentrated to afford the target compound 2-fluoro-3-methyl-5-nitropyridine as a solid (8.4 g, 60% yield). The product was identified by 1H NMR (DMSO-d6, 300 MHz): δ 2.42 (s, 3H), 8.43 (m, 1H), 8.95 (dd, J = 1.6 Hz, 1H); mass spectrum (CI/NH3) m/z: 157 (M + H)+.

References

[1] Patent: US5733912, 1998, A

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