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Growth hormone releasing peptide

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Growth hormone releasing peptide Basic information

Product Name:
Growth hormone releasing peptide
Synonyms:
  • D-TRP7,ALA8,D-PHE10]-A-MELANOCYTESTIMULATINGHORMONEAMIDEFRAGMENT6-11
  • (2S)-6-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(3H-imidazol-4-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenyl-propanoyl]amino]hexanamide
  • Growth hormone releasing peptide
  • (D-trp7,ala8,D-phe10)-A-melanocyte*stimulating ho
  • (D-TRP7,ALA8,D-PHE10)-A-MELANOCYTE*STIMU LATING HORM
  • Growth
  • [d-trp7, ala8, d-phe10]-α-melanocyte stimulating hormone amide fragment 6-11
  • High Purity Ghrp-6 Peptide For Lean Muscle Mass CAS NO.87616-84-0 CAS NO.87616-84-0
CAS:
87616-84-0
MF:
C46H56N12O6
MW:
873.01
EINECS:
212-729-3
Product Categories:
  • Peptide
  • GHRP6
  • hgh
  • 87616-84-0
Mol File:
87616-84-0.mol
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Growth hormone releasing peptide Chemical Properties

Melting point:
>160o C (Dec.)
Boiling point:
1407.0±65.0 °C(Predicted)
Density 
1.333±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
Methanol (Slightly), Water (Slightly)
form 
Solid
pka
13.42±0.46(Predicted)
color 
White to Off-White
Sequence
is-D-Trp-Ala-Trp-D-Phe-Lys-NH2|H-His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
InChI
InChI=1S/C46H56N12O6/c1-27(54-44(62)39(20-29-23-51-35-15-7-5-13-32(29)35)57-43(61)34(48)22-31-25-50-26-53-31)42(60)56-40(21-30-24-52-36-16-8-6-14-33(30)36)46(64)58-38(19-28-11-3-2-4-12-28)45(63)55-37(41(49)59)17-9-10-18-47/h2-8,11-16,23-27,34,37-40,51-52H,9-10,17-22,47-48H2,1H3,(H2,49,59)(H,50,53)(H,54,62)(H,55,63)(H,56,60)(H,57,61)(H,58,64)/t27-,34-,37-,38+,39+,40-/m0/s1
InChIKey
WZHKXNSOCOQYQX-FUAFALNISA-N
SMILES
C(N)(=O)[C@H](CCCCN)NC(=O)[C@@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1C2=C(C=CC=C2)NC=1)NC(=O)[C@H](C)NC(=O)[C@@H](CC1C2=C(C=CC=C2)NC=1)NC(=O)[C@H](CC1N=CNC=1)N
CAS DataBase Reference
87616-84-0(CAS DataBase Reference)
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Safety Information

WGK Germany 
3
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Growth hormone releasing peptide Usage And Synthesis

Description

Growth hormone-releasing peptides (GHRPs) are synthetic, non-natural peptides endowed with potent stimulatory effects on somatotrope secretion in animals and humans. They have no structural homology with GHRH and act via specific receptors present either at the pituitary or the hypothalamic level both in animals and in humans.

Uses

L-Histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide is a growth hormone releasing peptide.

Uses

Growth hormone releasing peptide-6 can promote the secretion of growth hormone, regulate food intake, increase weight, and promote animal growth.

benefits

When Growth hormone releasing peptide is administered, a selective pulse is sent to the brain that stimulates the hypothalamus and anterior pituitary to release growth hormones. Once this pulse is sent, the cells go directly to the muscle to support development while staying clear of any possible bone or cartilage growth. When the Peptide is injected it increases cell synthesis, elevates secretion levels of insulin from pancreatic tissue, and increases ghrelin in the stomach—which helps release GH and control hunger. All of these functions work to promote fat loss, shuttling of nutrients, and building clean muscle mass.

Mechanism of action

Growth hormone releasing peptide is generally accepted that GHRPs stimulate the release of GH by acting at the level of the pituitary through a receptor different to that for the endogenous GH-releasing hormone (GHRH). In addition, it has been reported that there are specific binding sites for these peptides in the hypothalamus and that systemic administration of GHRPs increases the expression of the immediate early gene c-fos in a subpopulation of hypothalamic neurons.

Side effects

Carpal tunnel syndrome.Increased insulin resistance.
Type 2 diabetes.
Swelling in the arms and legs (edema)
Joint and muscle pain.
For men, enlargement of breast tissue (gynecomastia).
Increased risk of certain cancers.

Physiological effects

Growth hormone releasing peptide (GHRP) is a cyclase inhibitor that blocks the release of endogenous growth hormone.The peptide acts on both igf-i and somatotrophs, with receptor activity in the hypothalamus.GHRP can be used to increase body weight and control obesity.It has been shown to stimulate cell division and inhibit apoptosis in vitro.

Solubility in water

It is recommended to reconstitute the lyophilized growth hormone releasing peptide in sterile 18MΩ-cm H2O not less than 100 μg/ml, which can then be further diluted to other aqueous solutions.

storage

Lyophilized Growth hormone releasing peptide although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Growth hormone releasing peptide should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Growth hormone releasing peptideSupplier

Zhangzhou Sinobioway Peptide Co. Ltd. Gold
Tel
15659861111 18859245923
Email
peptideplatform@gmail.com
Shanghai Boyle Chemical Co., Ltd.
Tel
Email
sales@boylechem.com
Alabiochem Tech.Co., Ltd.
Tel
0512-58900862 400-0707518
Email
sales@alabiochem.com
LGM Pharma
Tel
1-(800)-881-8210
Email
inquiries@lgmpharma.com
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com