ANTI-BRDU Chemical Properties

storage temp. 

−20°C

form 

buffered aqueous solution

biological source

mouse

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

3

Storage Class

10 - Combustible liquids

MSDS

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ANTI-BRDU Usage And Synthesis

Uses

Monoclonal Anti-BrdU antibody has been used in immunostaining, BrdU incorporation into DNA, immunohistochemistry and uterine labeling index. It has also been used to investigate cell proliferation.

General Description

Anti-Bromodeoxyuridine is a monoclonal antibody to 5-bromo-2′-deoxyuridine-5′-monophosphate.

Biochem/physiol Actions

5-Bromodeoxyuridine (BrdU) is an analogue of thymidine, used to measure DNA synthesis immunochemically in living cells. BrdU along with cAMP and butyrate plays a vital role in the cellular differentiation in several mammalian cell types. It also inhibits cell growth in mammalian and yeast cells by modulating the expression of particular genes involved in cell division. In the absence of DNA synthesis, brdu promotes mouse neuroblastoma C1300 cell differentiation into cells that morphologically are similar to mature neurons. BrdU activates cell senescence-like phenomenon in mammalian cells.