1-Boc-3-piperidone Chemical Properties

Melting point:

35-40 °C (lit.)

Boiling point:

289.8±33.0 °C(Predicted)

Density 

1.099±0.06 g/cm3(Predicted)

Flash point:

>230 °F

storage temp. 

2-8°C

pka

-1.71±0.20(Predicted)

form 

Liquid

color 

Clear colorless

Water Solubility 

It is insoluble in water.

BRN 

5936353

InChI

InChI=1S/C10H17NO3/c1-10(2,3)14-9(13)11-6-4-5-8(12)7-11/h4-7H2,1-3H3

InChIKey

RIFXIGDBUBXKEI-UHFFFAOYSA-N

SMILES

N1(C(OC(C)(C)C)=O)CCCC(=O)C1

CAS DataBase Reference

98977-36-7(CAS DataBase Reference)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

HazardClass 

KEEP COLD

HS Code 

29339900

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

1-Boc-3-piperidone Usage And Synthesis

Chemical Properties

White to yellow low melting solid

Uses

1-Boc-3-piperidone, is used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.

Synthesis

With 179g compound 3(1-BOC-3-piperidines alcohol) drop in the 2L reaction flask, drop into pimelinketone 1300g, aluminum isopropylate 88g, methylene dichloride 400ml is warming up to 80 ℃, insulation reaction 8h, reaction finishes to be cooled to room temperature, adds 10% sodium hydroxide 200ml, stirring at normal temperature 30min, filter, the filtrate normal pressure reclaims methylene dichloride, reclaim under reduced pressure pimelinketone again, reclaim finish after, add the 300ml dichloromethane extraction three times, it is dry concentrated to merge oil reservoir, gets 1-BOC-3-piperidone crude product.
Refining: with 1-BOC-3-piperidone crude product is that 60pa, temperature are to distill under 104 ~ 105 ℃ the condition at pressure, gets 1-BOC-3-piperidone elaboration 163g, 92.9%.

1-Boc-3-piperidone(98977-36-7)Related Product Information

• tert-Butyl peroxybenzoate
• Buprofezin
• Butylparaben
• 4,4-Piperidinediol hydrochloride
• 3-Piperidinone
• 2-Piperidone
• Butyl benzoate
• tert-Butyl carbazate
• tert-Butanol
• Cyhalofop-butyl
• Diisobutyl phthalate
• Haloperidol
• Butyl acrylate
• 2-Butoxyethanol
• RESMETHRIN
• Butyl acetate
• Isobutyl chloroformate
• N-(tert-Butoxycarbonyl)-4-piperidone