1-Methylpyrazole Chemical Properties

Melting point:

36.5°C (estimate)

Boiling point:

127 °C

Density 

0.988 g/mL at 20 °C (lit.)

refractive index 

n20/D 1.477

Flash point:

35 °C

storage temp. 

Inert atmosphere,Room Temperature

Water Solubility 

Soluble in water

pka

2.25±0.10(Predicted)

form 

Liquid

color 

Clear colorless to light yellow

BRN 

105207

InChI

InChI=1S/C4H6N2/c1-6-4-2-3-5-6/h2-4H,1H3

InChIKey

UQFQONCQIQEYPJ-UHFFFAOYSA-N

SMILES

N1(C)C=CC=N1

CAS DataBase Reference

930-36-9(CAS DataBase Reference)

NIST Chemistry Reference

1-methylpyrazole(930-36-9)

Safety Information

Hazard Codes 

Xi

Risk Statements 

10-36/37/38

Safety Statements 

26-37/39-16

RIDADR 

UN 1993 3/PG 3

WGK Germany 

3

F 

10

HazardClass 

3

PackingGroup 

III

HS Code 

29331990

MSDS

• Language:English Provider:1-Methylpyrazole
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
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1-Methylpyrazole Usage And Synthesis

Chemical Properties

clear colorless to light yellow liquid

Uses

1-Methylpyrazole is a useful synthetic intermediate. It is used to synthesize heteroaryl(fluorophenyl)piperidinylindoles as α1 adrenoceptor antagonists. It is also used to prepare quinazoline derivatives as glucokinase activators.

Definition

ChEBI: A member of the class of pyrazoles that is the 1-methyl derivative of 1H-pyrazole.

Synthesis

1-Methylpyrazole was prepared by the condensation of 1,1,3,3-tetraethoxypropane with methylhydrazine[1].

References

[1] Peggy W. Alley, David A. Shirley. “The Metalation of 1-Phenyl- and 1-Methylpyrazole with n-Butyllithium.” Journal of the American Chemical Society 80 23 (1958): 6271–6274.

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