4-Chloro-4'-hydroxybenzophenone Chemical Properties

Melting point:

177-181 °C

Boiling point:

257 °C (13 mmHg)

Density 

1.2082 (rough estimate)

refractive index 

1.5434 (estimate)

Flash point:

100 °C

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly, Sonicated)

pka

7.68±0.15(Predicted)

color 

Pale Beige to Light Brown

BRN 

2049956

CAS DataBase Reference

42019-78-3(CAS DataBase Reference)

NIST Chemistry Reference

Methanone, (4-chlorophenyl)(4-hydroxyphenyl)-(42019-78-3)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-20/21/22

Safety Statements 

24/25-37/39-26-36

Hazard Note 

Irritant

HS Code 

29144000

MSDS

• Language:English Provider:(4-Chlorophenyl)(4-hydroxyphenyl)-Methanone
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-Chloro-4'-hydroxybenzophenone Usage And Synthesis

Chemical Properties

light grey to beige-brown powder

Uses

4-Chloro-4’-hydroxybenzophenone (Fenofibrate EP Impurity A; Fenofibrate USP Related Compound A) the impurity of Fenofibric acid (42017-89-0), the active metabolite of fenofibrate which increases Apolipoprotein A-I–Mediated High-Density Lipoprotein Biogenesis by enhancing transcription of ATP-Binding cassette transporter A1 gene in a liver X receptor–dependent manner.

Preparation

Preparation by Fries rearrangement of phenyl p-chloro-benzoate,
? in the presence of aluminium chloride, without solvent, at 160° for 5 min, between 120° and 160° (good yield) or at 130° for 1 h, then at 160° for 1 h (10%) or in refluxing chlorobenzene for 10 h (52%);
? in the presence of trifluoromethanesulfonic acid at 45–55° (94%).

4-Chloro-4'-hydroxybenzophenone(42019-78-3)Related Product Information

• 4-Hydroxybenzophenone
• 4-Chlorobenzophenone
• 3,4-Dihydroxybenzophenone
• Glycolic acid
• 4,4'-Dihydroxybenzophenone
• 4-Hydroxybenzaldehyde
• 2,4-Dihydroxybenzophenone
• Benzophenone
• Hydroxy silicone oil
• Hydroxyapatite
• Fenofibric acid
• Fenofibrate
• FENOFIBRATE RELATED COMPOUND C (25 MG) (1-METHYLETHYL 2-[[2-[4-(4-CHLOROBENZOYL)PHENOXY]-2-METHYLPROPANOYL]OXY]-2-METHYLPROPANOATE)
• (4-Chlorophenyl)[4-(1-Methylethoxy)phenyl]Methanone (Fenofibrate IMpurity)
• 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropionic acid methyl ester
• Unii-4bmh7izt98
• 3-[4-(4-Chlorobenzoyl)phenoxy]-2-butanone (Fenofibrate IMpurity)
• FENOFIBRIC ACID ETHYL ESTER