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(TRIMETHYLSILYL)ACETIC ACID

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(TRIMETHYLSILYL)ACETIC ACID Basic information

Product Name:
(TRIMETHYLSILYL)ACETIC ACID
Synonyms:
  • (trimethylsilyl)-aceticaci
  • TriMethylsilyl)acetic ac
  • (TRIMETHYLSILYL)ACETIC ACID
  • 2-(TRIMETHYLSILYL)ACETIC ACID
  • (Trimethylsilyl)acetic acid, 98+%
  • 2-trimethylsilylacetate
  • Acetic acid, 2-(trimethylsilyl)-
  • DK685
CAS:
2345-38-2
MF:
C5H12O2Si
MW:
132.23
EINECS:
219-067-4
Product Categories:
  • Building Blocks
  • C1 to C5
  • Carbonyl Compounds
  • Carboxylic Acids
  • Chemical Synthesis
  • Organic Building Blocks
  • Si (Classes of Silicon Compounds)
  • Si-(C)4 Compounds
  • Silicon Compounds (for Synthesis)
  • Synthetic Organic Chemistry
  • C1 to C5
  • Carbonyl Compounds
  • Carboxylic Acids
Mol File:
2345-38-2.mol
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(TRIMETHYLSILYL)ACETIC ACID Chemical Properties

Melting point:
39-42 °C(lit.)
Boiling point:
90-95°C 10mm
Density 
0.8830 (estimate)
Flash point:
203 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
Sol ethereal solvents.
form 
solid
pka
5.23±0.10(Predicted)
Hydrolytic Sensitivity
4: no reaction with water under neutral conditions
Sensitive 
Moisture Sensitive
BRN 
1679394
CAS DataBase Reference
2345-38-2(CAS DataBase Reference)
NIST Chemistry Reference
Acetic acid, (trimethylsilyl)-(2345-38-2)
EPA Substance Registry System
Acetic acid, (trimethylsilyl)- (2345-38-2)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
RIDADR 
UN3261
WGK Germany 
2
RTECS 
AK0843500
3-10-21
TSCA 
No
HazardClass 
8
PackingGroup 
III

MSDS

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(TRIMETHYLSILYL)ACETIC ACID Usage And Synthesis

Physical properties

mp 40 °C.

Uses

(Trimethylsilyl)acetic acid may be used in chemical synthesis.

Uses

Trimethylsilylacetic Acid is a valuable reagent used in preparation of α,β-unsaturated carboxylic acids and α-trimethylsilylbutyrolactones,

Preparation

Obtained from the reaction of trimethylsilylmethylmagnesium chloride with carbon dioxide;3 can also be prepared by reaction of acetic acid with 2 equiv of lithium diisopropylamide, followed by chlorotrimethylsilane and hydrolysis.

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