KN-62 Chemical Properties

Melting point:

92-94°C

Boiling point:

964.7±75.0 °C(Predicted)

Density 

1.388

storage temp. 

-20°C

solubility 

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.93 mg/mL

form 

solid

pka

4.07±0.13(Predicted)

color 

white

CAS DataBase Reference

127191-97-3(CAS DataBase Reference)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

HS Code 

29339980

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

KN-62 Usage And Synthesis

Chemical Properties

Yellow Solid

Uses

A specific inhibitor of Ca2+/Calmodulin-dependent protein kinase II

Uses

selectively inhibits rat brain Ca2+/cadmodulin-dependent protein kinase II,

Uses

It is used as a potent and selective inhibitor of CaMKII. KN-62 has demonstrated potent and selective inhibition of Ca2+/calmodulin-dependent protein kinase II (CaMKII; Ki=0.9 ?M) which causes cells to arrest in the S phase. In HEK-293 cells expressing type III adenylyl cyclase (III-AC), 10 ?M of KN-62 blocked CaMKII phosphorylation of III-AC, and inhibited hormone-stimulated Ca2+ oscillations. Additionally, KN-62 is a potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM).

Definition

ChEBI: 5-isoquinolinesulfonic acid [4-[(2S)-2-[5-isoquinolinylsulfonyl(methyl)amino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl] ester is a member of piperazines.

General Description

A cell-permeable, reversible, and selective inhibitor of CaM kinase II (K_i = 900 nM for rat brain CaM kinase II) that binds directly to the calmodulin binding site of the enzyme. Also inhibits the growth of K562 cells in a dose-dependent manner.

Biological Activity

Selective, cell-permeable inhibitor of CaM kinase II (IC 50 = 0.9 μ M). Binds directly to the calmodulin binding site of the enzyme. Potent non-competitive antagonist at the P2X 7 receptor (IC 50 = 15 nM). Also available as part of the Mixed Kinase Inhibitor Tocriset™ .

Biochem/physiol Actions

Selectively inhibits rat brain Ca2+/calmodulin-dependent protein kinase II.

storage

-20°C (desiccate)

KN-62(127191-97-3)Related Product Information

• N-Aminoethylpiperazine
• 1-ACETYL-4-METHYLPIPERAZINE HYDROCHLORIDE
• 1-(3-PHENYLPROPYL)PIPERAZINE
• 5-Isoquinolinesulfonic acid
• 1-Acetylpiperazine
• 4-Methyl-1-piperazineethanamine
• 1-Piperazineethanamine,N,4-dimethyl-(9CI)
• 1-(4-phenylpiperazin-1-yl)propan-2-amine
• 1-(4-PHENYLPIPERAZIN-1-YL)ETHANONE
• 1-ETHYL-4-PHENYLPIPERAZINE
• N-[2-(4-HYDROXYPHENYL)ETHYL]-METHANESULFONAMIDE
• 2-(4-PHENYLPIPERAZIN-1-YL)ETHANAMINE
• KN-62
• N-phenethylmethanesulphonamide
• 1-(PROPANOYL)-PIPERAZINE
• KN-62 **NOT FOR SALE IN JAPAN**
• KN-62: HBC COMPLEX