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KN-62

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KN-62 Basic information

Product Name:
KN-62
Synonyms:
  • 1-(N,O-BIS-(5-ISOQUINOLINESULFONYL)-*N-M ETHYL-L-TYR
  • KN-62 97%
  • KN-62, 99+%
  • 4-((2S)-2-((5-isoquinolinylsulfonyl)methylamino)-3-oxo-3-(4-phenyl-1-piperazinyl)propyl)phenylisoquinolinesulfonicacid
  • 1-(N,O-Bis-[5-isoquinolinesulfonyl]-N-methyl-L-tyrosyl)-4-phenylpiperazine, (S)-5-Isoquinolinesulfonic Acid 4-(2-[(5-Isoquinolinylsulfonyl)methylamino]- 3-oxo-3-[4-phenyl-1-piperazinyl]propyl)phenyl Ester,
  • 5-Isoquinolinesulfonic acid, 4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester
  • (s)-5-isoquinolinesulfonic acid 4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester
  • CS-756
CAS:
127191-97-3
MF:
C38H35N5O6S2
MW:
721.84
Product Categories:
  • Inhibitor
  • Protein Kinase
  • Protein Kinase Inhibitors and Activators
Mol File:
127191-97-3.mol
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KN-62 Chemical Properties

Melting point:
92-94°C
Boiling point:
964.7±75.0 °C(Predicted)
Density 
1.388
storage temp. 
-20°C
solubility 
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.93 mg/mL
pka
4.07±0.13(Predicted)
form 
solid
color 
white
CAS DataBase Reference
127191-97-3(CAS DataBase Reference)
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Safety Information

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29339980

MSDS

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KN-62 Usage And Synthesis

Chemical Properties

Yellow Solid

Uses

A specific inhibitor of Ca2+/Calmodulin-dependent protein kinase II

Uses

selectively inhibits rat brain Ca2+/cadmodulin-dependent protein kinase II,

Biological Activity

Selective, cell-permeable inhibitor of CaM kinase II (IC 50 = 0.9 μ M). Binds directly to the calmodulin binding site of the enzyme. Potent non-competitive antagonist at the P2X 7 receptor (IC 50 = 15 nM). Also available as part of the Mixed Kinase Inhibitor Tocriset™ .

KN-62Supplier

J & K SCIENTIFIC LTD.
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010-82848833- ;010-82848833-
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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sh@meryer.com
3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801
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3bsc@sina.com
Chembest Research Laboratories Limited
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Chemsky(shanghai)International Co.,Ltd.
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021-50135380
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shchemsky@sina.com