ECHINULIN Chemical Properties

Melting point:

242-243°

alpha 

D20 -26.0° (chloroform)

Boiling point:

695.3±55.0 °C(Predicted)

Density 

1.068±0.06 g/cm3(Predicted)

solubility 

Methanol: soluble

form 

A solid

pka

13.05±0.60(Predicted)

color 

White to off-white

ECHINULIN Usage And Synthesis

Description

Echinulin is a diketopiperazine metabolite found in fungi that, when administered to rabbits, at a dose of 10 mg/kg, leads to liver and lung damage. It has no activity at the δ, κ, or μ-opioid receptors or the cannabinoid CB₁ and CB₂ receptors.

Uses

Echinulin is a metabolite of diketopiperazine.

Definition

ChEBI: Echinulin is an indole alkaloid with formula C29H39N3O2. It is a fungal metabolite found in several Aspergillus species. It has a role as an Aspergillus metabolite, a marine metabolite and a plant metabolite. It is a member of indoles, a member of 2,5-diketopiperazines, an olefinic compound and an indole alkaloid.

IC 50

NF-κB

References

[1] MUSLIM ALI . Toxicity of echinulin from Aspergillus chevalieri in rabbits[J]. Toxicology letters, 1989, 48 3: Pages 235-241. DOI: 10.1016/0378-4274(89)90049-0
[2] JIANGTAO GAO. Benzyl Derivatives with in Vitro Binding Affinity for Human Opioid and Cannabinoid Receptors from the Fungus Eurotium repens[J]. Journal of Natural Products , 2011, 74 7: 1636-1639. DOI: 10.1021/np200147c

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