2-Bromo-4-fluorophenol Chemical Properties

Melting point:

43-45 °C (lit.)

Boiling point:

89 °C/1 mmHg (lit.)

Density 

1.744

refractive index 

1.554

Flash point:

185 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

Crystalline Solid

pka

8.44±0.18(Predicted)

color 

Light brown to brown

BRN 

2355593

InChI

InChI=1S/C6H4BrFO/c7-5-3-4(8)1-2-6(5)9/h1-3,9H

InChIKey

MEYRABVEYCFHHB-UHFFFAOYSA-N

SMILES

C1(O)=CC=C(F)C=C1Br

CAS DataBase Reference

496-69-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38

Safety Statements 

26-36/37/39

RIDADR 

3276

WGK Germany 

3

Hazard Note 

Irritant

PackingGroup 

III

HS Code 

29071990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Bromo-4-fluorophenol Usage And Synthesis

Chemical Properties

light brown to brown crystalline solid

Uses

2-Bromo-4-fluorophenol was used in preparation of 4,4-difluoro-2-bromo-cyclohexadienone and 6-(aminomethylphenoxy)benzoxaborole analogs.

Synthesis

GENERAL METHOD: BiCl3 (30 mol%) was added to a stirred solution of MeCN/H2O (5:0.1 mL; 5:0.1 v/v) containing MOM-protected phenol (1 mmol). The reaction mixture was stirred at 50 °C until the reaction was complete (monitored by TLC). Upon completion of the reaction, the mixture was filtered using CH2Cl2 (10 mL) over a pad of diatomaceous earth. The filtrate was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent hexane/EtOAc mixture) to afford the target product 2-bromo-4-fluorophenol in 76-95% yield. All phenolic products were analyzed by IR and NMR spectroscopy and verified by comparison with real samples.

References

[1] Synthetic Communications, 2016, vol. 46, # 7, p. 586 - 593

2-Bromo-4-fluorophenol(496-69-5)Related Product Information

• 4-Bromophenol
• 4-Trifluoromethylphenol
• 3-Bromophenol
• 4-Fluorophenol
• Ethyl bromodifluoroacetate
• Bromine
• BROMOTRIFLUOROMETHANE
• 2-Bromo-4,6-difluoroanisole
• 2-Bromo-4,5-difluorophenol
• 2-Bromo-4,5-difluoroanisole
• 2,6-DIBROMO-4-FLUOROPHENOL
• 2-Bromo-4-fluoroanisole
• 2-Bromo-4,6-difluorophenol
• 1-(2-BROMO-4,6-DIFLUOROPHENOXY)-2-CHLOROETHANE
• 2-BROMO-6-CHLORO-4-FLUOROPHENOL
• 2-BROMO-6-CHLORO-4-FLUOROANISOLE
• 4-AMINO-3-BROMO-5-FLUOROPHENOL
• 4-Bromo-3-fluorophenol 99%,4-Bromo-3-fluorophenol99%,4-BROMO-3-FLUOROPHENOL