5-PYRIDIN-4-YL-1H-INDAZOLE Chemical Properties

Boiling point:

419.1±20.0 °C(Predicted)

Density 

1.270±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMF (Slightly), DMSO (Slightly)

form 

Solid

pka

13.13±0.40(Predicted)

color 

Pale Yellow

5-PYRIDIN-4-YL-1H-INDAZOLE Usage And Synthesis

Uses

TG693 is an orally active inhibitor of CLK1. TG693 regulates the mutated exon 31 of the dystrophin gene in vivo. TG693 is used in Duchenne muscular dystrophy (DMD) research[1].

References

[1] Sako Y, et al. Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy. Sci Rep. 2017 May 30;7:46126. DOI:10.1038/srep46126

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