BENZYL PHENYL SULFONE Chemical Properties

Melting point:

146-150 °C

Boiling point:

344.47°C (rough estimate)

Density 

1.2321 (rough estimate)

refractive index 

1.5200 (estimate)

storage temp. 

Sealed in dry,Room Temperature

form 

Crystalline Powder

color 

Off-white

BRN 

2049938

CAS DataBase Reference

3112-88-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

36/37/38-22

Safety Statements 

36/37/39-26

RTECS 

WR2700000

HS Code 

29041000

MSDS

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• Language:English Provider:ALFA

BENZYL PHENYL SULFONE Usage And Synthesis

Application

Benzylphenyl sulfone can be used as a pharmaceutical synthesis intermediate. In existing research on the selective oxidation of thioethers to sulfone compounds, acids, metal oxides, organic peroxides, inorganic peroxides, and halogens are commonly used as oxidants.

Chemical Properties

off-white crystalline powder

Synthesis Reference(s)

Synthetic Communications, 20, p. 925, 1990 DOI: 10.1080/00397919008052793
Tetrahedron Letters, 8, p. 3299, 1967

Synthesis

100 mLSchlenk reaction tube was sequentially added TEMPO (3.9 mg, 0.025 mmol), methanol (1 mL), CuSO (4.0 mg, 0.025 mmol), 3,5-dimethylpyridine (28.2 ??L, 0.25 mmol), benzene sulfide (58.8 ??L, 0.5 mmol), filled with 1 atm oxygen, sealed reaction tube heated to 65 ?? reaction 72h. After the reaction was cooled to room temperature, add appropriate amount of ethyl acetate, the reaction solution of blue solid precipitation, filtration, concentration under reduced pressure, through the column chromatography, the filtrate. The reaction tube was sealed and heated to 65 ?? for 72 h. At the end of the reaction, the reaction was cooled to room temperature, appropriate amount of ethyl acetate was added, and a blue solid was precipitated in the reaction solution, which was filtered, and the filtrate was concentrated under reduced pressure, and purified by column chromatography to obtain the product with a yield of 82%.

BENZYL PHENYL SULFONE(3112-88-7)Related Product Information

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