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D(-)-Norvaline

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D(-)-Norvaline Basic information

Product Name:
D(-)-Norvaline
Synonyms:
  • H-D-NVA-OH
  • H-D-NHCH[CH3(CH2)2]-COOH
  • H-D-NORVALINE
  • H-D-APE(2)-OH
  • D-NVal-OH
  • H-D-2-AMINOVALERIC ACID
  • D-Nva-OH
  • D-Nval
CAS:
2013-12-9
MF:
C5H11NO2
MW:
117.15
EINECS:
217-936-2
Product Categories:
  • Amino Acids
  • Peptide
  • Norvaline [Nva]
  • bc0001
Mol File:
2013-12-9.mol
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D(-)-Norvaline Chemical Properties

Melting point:
>300 °C(lit.)
alpha 
-24 º (c=5, 5N HCl)
Boiling point:
222.9±23.0 °C(Predicted)
Density 
1.2000 (estimate)
refractive index 
-25 ° (C=10, 6mol/L HCl)
storage temp. 
Store at RT.
solubility 
Aqueous Acid (Slightly), Water (Slightly)
form 
Solid
pka
2.54±0.20(Predicted)
color 
White to Off-White
optical activity
[α]20/D 24°, c = 10 in 5 M HCl
Water Solubility 
SOLUBLE
Merck 
14,6716
BRN 
1721161
CAS DataBase Reference
2013-12-9(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
22-24/25-37/39-26
WGK Germany 
3
HS Code 
29224919

MSDS

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D(-)-Norvaline Usage And Synthesis

Chemical Properties

white to off-white crystals or crystalline powder

Uses

D-Norvaline is used as a catalyst in the enantioselective α-bromination of carbonyl and 1,3-dicarbonyl compounds. D-Norvaline is also incorporated into jadomycins (a group of compounds that are widely used as antibiotics), ultimately producing compounds that have potential antiproliferative/anti-cancer properties.

Definition

ChEBI: D-2-aminopentanoic acid is a 2-aminopentanoic acid that has R-configuration. It has a role as an EC 6.1.1.4 (leucine--tRNA ligase) inhibitor. It is a D-alpha-amino acid and a 2-aminopentanoic acid. It is an enantiomer of a L-2-aminopentanoic acid.

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