3-NITRO-6-PYRIDINEMETHANOL Chemical Properties

Boiling point:

327.6±27.0 °C(Predicted)

Density 

1.422±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

pka

12.92±0.10(Predicted)

Appearance

Light yellow to yellow Solid

3-NITRO-6-PYRIDINEMETHANOL Usage And Synthesis

Synthesis

NaBH4 (82 mg, 2.3 mmol, 1.0 eq.) was added in batches to a stirred solution of 5-nitropyridine-2-carbaldehyde (350 mg, 2.3 mmol, 1.0 eq.) in methanol (10 mL) at 0 °C, keeping the reaction temperature at 0 °C and stirring continuously for 2 hours. After the reaction was completed, the solvent was removed by evaporation under reduced pressure, the residue was dissolved in ethyl acetate (20 mL), the organic phase was washed with saturated brine (30 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give (5-nitropyridin-2-yl)methanol (210 mg, 60% yield) as a light yellow solid.

References

[1] Patent: WO2013/13815, 2013, A1. Location in patent: Page/Page column 231
[2] Patent: US2013/29962, 2013, A1. Location in patent: Paragraph 1111

3-NITRO-6-PYRIDINEMETHANOL(36625-57-7)Related Product Information

• methyl 5-nitro-6-methyl-2-pyridinecarboxylate
• Methyl 4-amino-5-nitro-2-pyridinecarboxylate
• 5-Nitropyridine-2-carboxylic acid
• 3-NITRO-6-PYRIDINEMETHANOL
• Methyl 5-nitro-2-pyridinecarboxylate
• 4-METHYL-5-NITRO-2-PYRIDINECARBOXYLIC ACID
• 2-Pyridinecarboxylicacid,5-nitro-,ethylester(9CI)
• 2-Methyl-3-nitropyridine-6-carboxylic acid
• 6-METHYL-5-NITRO-2-PYRIDINEMETHANOL