Basic information Safety Supplier Related

(+)-Cloprostenol

Basic information Safety Supplier Related

(+)-Cloprostenol Basic information

Product Name:
(+)-Cloprostenol
Synonyms:
  • (+)-9ALPHA,11ALPHA,15-TRIHYDROXY-16-(3-CHLOROPHENOXY)-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID
  • (+)-16-M-CHLOROPHENOXY TETRANOR PROSTAGLANDIN F2ALPHA
  • Superphan
  • (+)-Cloprostenol
  • cGMP Superphan
  • (5Z)-7-[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-Chlorophenoxy)-3-hydroxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-5-heptenoic acid
  • (Z)-7-((1R,2R,3R,5S)-2-((R,E)-4-(3-Chlorophenoxy)-3-hydroxybut-1-en-1-yl)-3,5-dihydroxycyclopentyl)hept-5-enoic acid
  • 5-Heptenoic acid, 7-[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-chlorophenoxy)-3-hydroxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-, (5Z)-
CAS:
54276-21-0
MF:
C22H29ClO6
MW:
424.92
Mol File:
54276-21-0.mol
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(+)-Cloprostenol Chemical Properties

Boiling point:
628.0±55.0 °C(Predicted)
Density 
1.321
storage temp. 
Store at -20°C
solubility 
DMF: >100 mg/ml (from Fluprostenol); DMSO: >100 mg/ml (from Fluprostenol; Ethanol: >100 mg/ml (from Fluprostenol); PBS pH 7.2: >16 mg/ml (from Fluprostenol)
pka
4.76±0.10(Predicted)
form 
Oil
color 
Colorless to light yellow
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(+)-Cloprostenol Usage And Synthesis

Uses

(+)-Cloprostenol is a prostaglandin F2α (PGF2α) analogue, and shows selective agonistic activity at the prostaglandin receptor.

Definition

ChEBI: Cloprostenol is a prostanoid.

in vivo

D-cloprostenol (15 g per head) is the lowest dose that consistently achieves abortion; D-cloprostenol causes mild adverse effects including salivation, defecation and hyperventilation in bitches weighing less than 10 kg. Intra-vesicle administration of a single low dose of d-cloprostenol is a safe and successful technique to induce abortion in the bitch[1].

IC 50

PGF2α

References

[1] Manca R, et al. Intra-vesicle administration of D-cloprostenol for induction of abortion in mid-gestation bitches. Anim Reprod Sci. 2008 Jun;106(1-2):133-42. Epub 2007 Apr 21. DOI:10.1016/j.anireprosci.2007.04.011
[2] Re G, et al. Specific binding of dl-cloprostenol and d-cloprostenol to PGF2 alpha receptors in bovine corpus luteum and myometrial cell membranes. J Vet Pharmacol Ther. 1994 Dec;17(6):455-8. DOI:10.1111/j.1365-2885.1994.tb00277.x

(+)-CloprostenolSupplier

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