METHYL 7-HYDROXYCOUMARIN-4-ACETATE Chemical Properties

Melting point:

221-223 °C

Boiling point:

220 °C

Density 

1.368±0.06 g/cm3(Predicted)

pka

7.69±0.20(Predicted)

form 

Solid

color 

White to light yellow

Safety Information

Risk Statements 

41

Safety Statements 

39

HazardClass 

IRRITANT

METHYL 7-HYDROXYCOUMARIN-4-ACETATE Usage And Synthesis

Uses

Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate, a natural coumarins derivative, is exploited for the synthesis of the switchable fluorescent substrates to be used in bacterial enzyme detection[1][2][3].

References

[1] Nascimento JSD, et al. Mapping the Biotransformation of Coumarins through Filamentous Fungi. Molecules. 2019 Sep 29;24(19). DOI:10.3390/molecules24193531
[2] Lizzul-Jurse A, et al. Readily functionalizable phosphonium-tagged fluorescent coumarins for enhanced detection of conjugates by mass spectrometry. Org Biomol Chem. 2016 Aug 10;14(32):7777-91. DOI:10.1039/c6ob01080f
[3] Giovannini G, et al. Coumarin-based, switchable fluorescent substrates for enzymatic bacterial detection. Talanta. 2018 Oct 1;188:448-453. DOI:10.1016/j.talanta.2018.06.018

METHYL 7-HYDROXYCOUMARIN-4-ACETATE(15991-13-6)Related Product Information

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