CYLD ANTIBODY Usage And Synthesis

Source

Rabbit

Reactivity

Human;Monkey

Background

CYLD is a cytoplasmic deubiquitinating enzyme encoded by a tumor suppressor gene altered in individuals diagnosed with cylindromatosis, a genetic condition characterized by benign tumors of skin appendages. Functional CYLD deubiquitinase regulates inflammation and cell proliferation by down regulating NF-κB signaling through removal of ubiquitin chains from several NF-κB pathway proteins. CYLD is a negative regulator of proximal events in Wnt/β-catenin signaling and is a critical regulator of natural killer T cell development. The transcription factor Snail can inhibit CYLD expression, resulting in melanoma cell proliferation.

References

[1] Biggs, P.J. et al. (1995) Nat Genet 11, 441-3.
[2] Sun, S.C. (2010) Cell Death Differ 17, 25-34.
[3] Regamey, A. et al. (2003) J Exp Med 198, 1959-64.
[4] Glittenberg, M. and Ligoxygakis, P. (2007) Fly (Austin) 1, 330-2.
[5] Tauriello, D.V. et al. (2010) Mol Cell 37, 607-19.
[6] Lee, A.J. et al. (2010) EMBO J 29, 1600-12.
[7] Massoumi, R. et al. (2009) J Exp Med 206, 221-32.

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