2,5-Difluorophenylhydrazine hydrochloride Chemical Properties

Melting point:

210°C

storage temp. 

Sealed in dry,Room Temperature

Appearance

Light brown to yellow Solid

BRN 

8640307

CAS DataBase Reference

175135-73-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

20/21/22-36/37/38-22

Safety Statements 

22-36/37/39-36/37-26

RIDADR 

2811

Hazard Note 

Irritant

PackingGroup 

III

HS Code 

29280000

MSDS

• Language:English Provider:2,5-Difluorophenylhydrazine hydrochloride
• Language:English Provider:ALFA

2,5-Difluorophenylhydrazine hydrochloride Usage And Synthesis

Uses

2,5-Difluorophenylhydrazine, HCl

Synthesis

Using 2,5-difluoroaniline as raw material, in 3 times the amount of concentrated hydrochloric acid, glacial acetic acid as a co-solvent, and adding 3% of the mass of raw material PEG-400 as a phase-transfer catalyst, the diazotization reaction was carried out at -5 ?? 0 ?? for 1 h with 1.05 times the amount of molar sodium nitrite (prepared as an aqueous solution). 1.05 times the molar amount of sodium nitrite (prepared as an aqueous solution) -5 ~ 0 ?? under the condition of diazotization reaction for 1 h; sodium bisulfite as a reducing agent, diazotization solution 75 ?? reduction reaction 1h, the resulting reduction products were used as the phase transfer catalyst, and the phase transfer catalyst was used as the phase transfer catalyst. 1h, the obtained reduction product was acid precipitated by concentrated hydrochloric acid at 85 ?? for 2 h, . 2,5-difluorophenylhydrazine hydrochloride was prepared; finally, 2,5-difluorophenylhydrazine hydrochloride could be obtained by alkaline hydrolysis of 2,5-difluorophenylhydrazine hydrochloride with sodium hydroxide, the content ??96% (HPLC), the yield was ??74% (with 2,5-difluorophenylhydrazine hydrochloride). ??74% (as 2,5-difluorophenylhydrazine).

2,5-Difluorophenylhydrazine hydrochloride(175135-73-6)Related Product Information

• Topotecan hydrochloride
• DIPHENYLAMINE HYDROCHLORIDE
• Triethylamine hydrochloride
• Phenylhydrazine hydrochloride
• 4-Fluorophenylhydrazine hydrochloride
• D-Glucosamine hydrochloride
• Ethylenediamine dihydrochloride
• Hydrochloric acid
• 2,5-DIFLUOROPHENYLHYDRAZINE
• 3,5-DIFLUOROPHENYLHYDRAZINE HYDROCHLORIDE
• 3,4-DIFLUOROPHENYLHYDRAZINE HYDROCHLORIDE
• 2,4-DIFLUOROPHENYLHYDRAZINE HYDROCHLORIDE,2,4-Difluorophenylhydrazine hydrochloride 97%
• 3,4-DIFLUOROPHENYLHYDRAZINE HYDROCHLORIDE
• PENTAFLUOROPHENYLHYDRAZINE HYDROCHLORIDE
• 2,5-Difluorophenylhydrazine hydrochloride
• 2,6-DIFLUOROPHENYLHYDRAZINE HYDROCHLORIDE
• 2-CHLORO-4-CYANO-3,5,6-TRIFLUOROPHENYLHYDRAZINE
• 1-(2,3,5,6-TETRAFLUORO-4-METHYLPHENYL)-4-(4-CHLOROPHENYL)THIOSEMICARBAZIDE