BUB3 ANTIBODY Usage And Synthesis

Source

Rabbit

Applications

BUB3 antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Recommended starting dilution is 1:1000.

Reactivity

Human;Mouse;Rat;Hamster;Monkey

Immunogen

Anti-human BUB3 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human BUB3 protein 1-328 amino acids purified from E. coli.

Background

Mitotic checkpoint protein BUB3 (BUB3), is a saved component of the mitotic spindle assembly complex (MCC). The encoded protein has 4 WD repeat domains and has a similar sequence as the yeast BUB3 protein. BUB3 is vital for the kinetochore localization of BUB1 and BUBR1. BUB3 participates in the central spindle checkpoint pathway that operates during early embryogenesis. Furthermore BUB3 has a part in regulating the establishment of correct kinetochore-microtubule attachments.

References

[1] Fukagawa, T. (2008) Front Biosci 13, 2705-13.
[2] Chen, R.H. (2007) J Biomed Sci 14, 475-9.
[3] Dai, W. et al. (2004) Cancer Res 64, 440-5.
[4] Kops, G.J. et al. (2005) Nat Rev Cancer 5, 773-85.
[5] Baker, D.J. et al. (2004) Nat Genet 36, 744-9.
[6] Taylor, S.S. et al. (1998) J Cell Biol 142, 1-11.
[7] Logarinho, E. et al. (2008) Mol Biol Cell 19, 1798-813.

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