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Difenidol

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Difenidol Basic information

Product Name:
Difenidol
Synonyms:
  • 1,1-Diphenyl-4-(1-piperidinyl)-1-butanol
  • 1-Piperidinebutanol, alpha,alpha-diphenyl-
  • alpha,alpha-Diphenyl-1-piperidinebutanol
  • Benzhydrol, alpha-(3-piperidinopropyl)-
  • Nometic
  • SK&F No. 478-A
  • SK&F-478
  • SKF 478
CAS:
972-02-1
MF:
C21H27NO
MW:
309.45
EINECS:
213-540-9
Mol File:
972-02-1.mol
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Difenidol Chemical Properties

Melting point:
104-105°
Boiling point:
449.71°C (rough estimate)
Density 
1.0350 (rough estimate)
refractive index 
1.5614 (estimate)
NIST Chemistry Reference
Diphenidol(972-02-1)
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Safety Information

Hazardous Substances Data
972-02-1(Hazardous Substances Data)
Toxicity
LD50 s.c. in rats: 50 mg/kg (Goldenthal)

MSDS

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Difenidol Usage And Synthesis

Originator

Vontrol,SKF,US,1967

Uses

Anti-emetic.

Definition

ChEBI: A tertiary alcohol that is butan-1-ol substituted by two phenyl groups at position 1 and a piperidin-1-yl group at position 4.

Manufacturing Process

2.6 grams magnesium, activated by means of iodine, is introduced into 20 cc of absolute ether and is caused to react with 0.6 cc of ethyl
omide. While warming gently, 16.2 grams (0.1 mol) of N-[1-chloropropyl-(3)]-piperidine in 40 cc of absolute ether are added and, after adding a further 0.5 cc of ethyl
omide, 14.5 grams (0.08 mol) of benzophenone in 50 cc of anhydrous ether are added in portions. The magnesium is used up fairly quickly and, after 10 hours, only traces are left. In working up, both with hydrochloric acid and with ammonium chloride, the hydrochloride of diphenyl-3-piperidinopropyl carbinol is precipitated as a dense precipitate. It is purified by recrystallization from chloroform-ethyl acetate. MP 212-214°C.

Therapeutic Function

Antinauseant

Trade name

Vontrol (Smith Kline & French), Cephadol (Nippon Shinyaku).

DifenidolSupplier

Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
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sales@boylechem.com
Beijing HuaMeiHuLiBiological Chemical
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010-56205725
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waley188@sohu.com
Shanghai Chaolan Chemical Technology Center
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QQ:65489617 15618227136
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info@SuperLan-chem.com
Amadis Chemical Company Limited
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571-89925085
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sales@amadischem.com
Wuhan Magic Biological Technology Co., Ltd.
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18872289958、027-52304252、3400508168
Email
3400508168@qq.com