BENZIMIDAZO[2,1-A]BENZ[D,E]ISOQUINOLION-7-ONE
BENZIMIDAZO[2,1-A]BENZ[D,E]ISOQUINOLION-7-ONE Basic information
- Product Name:
- BENZIMIDAZO[2,1-A]BENZ[D,E]ISOQUINOLION-7-ONE
- Synonyms:
-
- 7h-benzimidazo(2,1-a)benz(de)isoquinolin-7-one
- luminoforyellow-green490rt
- luminogren
- 7H-Benzimidazo[2,1-a]benz[d,e]isoquinolin-7-one 98%
- 7H-Benzimidazo[2,1-a]benzo[de]isoquinolin-7-one
- BENZO(DE)BENZO(4,5)IMIDAZO(2,1-A)ISOQUINOLIN-7-ONE
- 7H-Benzimidazo[2,1-a]benz[d,e]isoquinolin-7-one98%
- 7H-Benzimidazo[2
- CAS:
- 23749-58-8
- MF:
- C18H10N2O
- MW:
- 270.28
- EINECS:
- 245-865-7
- Mol File:
- 23749-58-8.mol
BENZIMIDAZO[2,1-A]BENZ[D,E]ISOQUINOLION-7-ONE Chemical Properties
- Melting point:
- 189 °C
- Boiling point:
- 613.6±38.0 °C(Predicted)
- Density
- 1.40±0.1 g/cm3(Predicted)
- pka
- 2.05±0.20(Predicted)
- form
- powder
- color
- Bright yellow
BENZIMIDAZO[2,1-A]BENZ[D,E]ISOQUINOLION-7-ONE Usage And Synthesis
Uses
AHR agonist 3 is an aryl hydrocarbon receptor (AhR) agonist, that can induces cell cycle arrest or apoptosis via activation of tumor-suppressive transcriptional programs. AHR agonist 3 inhibits triple-negative breast cancer (TNBC) stem cell growth via AhR while exhibits minimal cytotoxicity against normal human primary cells and can be used for cancer research[1].
Properties and Applications
|
TEST ITEMS |
SPECIFICATION |
|
APPEARANCE |
YELLOW POWDER |
|
SHADE |
GREENISH |
|
HEAT RESISTANCE |
260 °C min |
|
LIGHT FASTNESS |
5-6 |
|
ACID RESISTANCE |
5 |
|
ALKALI RESISTANCE |
5 |
|
WATER RESISTANCE |
5 |
|
DENSITY |
1.20 g/cm 3 |
|
RESIDUE ON 80 MESH |
5.0% max |
|
WATER SOLUBLE |
1.0% max |
|
VOLATITE 105 °C |
1.0% max |
|
TINTING STRENGTH |
100-105 % |
|
WEIGHT METAL TOTAL |
50ppm max |
References
[1] Elson DJ, et.al. Induction of Aryl Hydrocarbon Receptor-Mediated Cancer Cell-Selective Apoptosis in Triple-Negative Breast Cancer Cells by a High-Affinity Benzimidazoisoquinoline. ACS Pharmacol Transl Sci. 2023 Jun 7;6(7):1028-1042. DOI:10.1021/acsptsci.2c00253
BENZIMIDAZO[2,1-A]BENZ[D,E]ISOQUINOLION-7-ONESupplier
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BENZIMIDAZO[2,1-A]BENZ[D,E]ISOQUINOLION-7-ONE(23749-58-8)Related Product Information
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- Bisbenzimidazo2,1-a:1',2'-b'anthra2,1,9-def:6,5,10-d'e'f'diisoquinoline-6,11-dione(mixturewithcis-isomer)